receptor interacting serine/threonine kinase 4

Target id: 2192

Nomenclature: receptor interacting serine/threonine kinase 4

Abbreviated Name: ANKRD3

Family: Receptor interacting protein kinase (RIPK) family

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for receptor interacting serine/threonine kinase 4 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 784 21q22.3 RIPK4 receptor interacting serine/threonine kinase 4
Mouse - 786 16 C4 Ripk4 receptor-interacting serine-threonine kinase 4
Rat - 786 11q12 Ripk4 receptor-interacting serine-threonine kinase 4
Previous and Unofficial Names
ANKK2 | ankyrin repeat domain 3 | DIK | PKC-delta-interacting protein kinase | PKK | protein kinase C-associated kinase | RIP4
Database Links
BRENDA
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.1
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: RIPK4
Ligand Sp. Type Action Affinity Units
lestaurtinib Hs Inhibitor Inhibition 7.9 pKd
TG-100-115 Hs Inhibitor Inhibition 7.0 pKd
staurosporine Hs Inhibitor Inhibition 7.0 pKd
KW-2449 Hs Inhibitor Inhibition 6.9 pKd
AST-487 Hs Inhibitor Inhibition 6.7 pKd
tamatinib Hs Inhibitor Inhibition 6.7 pKd
PP-242 Hs Inhibitor Inhibition 6.5 pKd
tozasertib Hs Inhibitor Inhibition 6.5 pKd
vandetanib Hs Inhibitor Inhibition 6.2 pKd
foretinib Hs Inhibitor Inhibition 6.1 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »
Clinically-Relevant Mutations and Pathophysiology
Disease:  Popliteal pterygium syndrome 2, lethal type
Synonyms: Bartsocas-Papas syndrome [Orphanet: ORPHA1234]
Popliteal pterygium syndrome [Disease Ontology: DOID:0060055]
Disease Ontology: DOID:0060055
OMIM: 263650
Orphanet: ORPHA1234

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

Receptor interacting protein kinase (RIPK) family: receptor interacting serine/threonine kinase 4. Last modified on 29/01/2016. Accessed on 21/08/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2192.