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Target not currently curated in GtoImmuPdb
Target id: 2201
Nomenclature: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Abbreviated Name: SMG1
Family: SMG1 subfamily
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | 3661 | 16p12.3 | SMG1 | SMG1 nonsense mediated mRNA decay associated PI3K related kinase | |
| Mouse | - | 3658 | 7 F1 | Smg1 | SMG1 nonsense mediated mRNA decay associated PI3K related kinase | |
| Rat | - | 3567 | 1q35 | Smg1 | SMG1, nonsense mediated mRNA decay associated PI3K related kinase | |
| Previous and Unofficial Names |
| ATX | LIP | SMG1 phosphatidylinositol 3-kinase-related kinase | SMG1, nonsense mediated mRNA decay associated PI3K related kinase | SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) | SMG1 | SMG1 homolog |
| Database Links |
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| Alphafold | Q96Q15 (Hs), Q8BKX6 (Mm) |
| BRENDA | 2.7.11.1 |
| CATH/Gene3D | 1.10.1070.11, 1.25.10.10 |
| ChEMBL Target | CHEMBL1795195 (Hs) |
| Ensembl Gene | ENSG00000157106 (Hs), ENSMUSG00000030655 (Mm), ENSRNOG00000047386 (Rn) |
| Entrez Gene | 23049 (Hs), 233789 (Mm), 691397 (Rn) |
| Human Protein Atlas | ENSG00000157106 (Hs) |
| KEGG Enzyme | 2.7.11.1 |
| KEGG Gene | hsa:23049 (Hs), mmu:233789 (Mm), rno:691397 (Rn) |
| OMIM | 607032 (Hs) |
| Pharos | Q96Q15 (Hs) |
| RefSeq Nucleotide | NM_015092 (Hs), NM_001031814 (Mm), XM_002728791 (Rn) |
| RefSeq Protein | NP_055907 (Hs), NP_001026984 (Mm), XP_002728837 (Rn) |
| UniProtKB | Q96Q15 (Hs), Q8BKX6 (Mm) |
| Wikipedia | SMG1 (Hs) |
| Enzyme Reaction |
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Download all structure-activity data for this target as a CSV file 
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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| General Comments |
| Given SMG1's role in ensuring integrity of translated proteins [1-2,4-5], and the observation that some disease phenotypes result from aberrant translation of truncated, partially functional proteins, SMG1 has become as a interventional molecular target. Therapeutic inhibitors of SMG1 are being sought [3]. |
1. Abraham RT. (2004) The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways. DNA Repair (Amst.), 3 (8-9): 919-25. [PMID:15279777]
2. Denning G, Jamieson L, Maquat LE, Thompson EA, Fields AP. (2001) Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein. J Biol Chem, 276 (25): 22709-14. [PMID:11331269]
3. Gopalsamy A, Bennett EM, Shi M, Zhang WG, Bard J, Yu K. (2012) Identification of pyrimidine derivatives as hSMG-1 inhibitors. Bioorg Med Chem Lett, 22 (21): 6636-41. [PMID:23021994]
4. Pulak R, Anderson P. (1993) mRNA surveillance by the Caenorhabditis elegans smg genes. Genes Dev, 7 (10): 1885-97. [PMID:8104846]
5. Yamashita A, Kashima I, Ohno S. (2005) The role of SMG-1 in nonsense-mediated mRNA decay. Biochim Biophys Acta, 1754 (1-2): 305-15. [PMID:16289965]
SMG1 subfamily: SMG1 nonsense mediated mRNA decay associated PI3K related kinase. Last modified on 27/03/2019. Accessed on 04/11/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2201.
