serine/threonine kinase 17b | Death-associated kinase (DAPK) family | IUPHAR/BPS Guide to PHARMACOLOGY

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serine/threonine kinase 17b

Target id: 2215

Nomenclature: serine/threonine kinase 17b

Abbreviated Name: DRAK2

Family: Death-associated kinase (DAPK) family

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for serine/threonine kinase 17b in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 372 2q33.1 STK17B serine/threonine kinase 17b
Mouse - 372 1 C1.1 Stk17b serine/threonine kinase 17b (apoptosis-inducing)
Rat - 371 9 q31 Stk17b serine/threonine kinase 17b
Previous and Unofficial Names
DAP kinase-related apoptosis-inducing protein kinase 2 | death-associated protein kinase-related 2
Database Links
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of human serine/threonine kinase 17B (STK17B) in complex with quercetin .
PDB Id:  3LM5
Ligand:  quercetin
Resolution:  2.29Å
Species:  Human
References: 
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of human serine/threonine kinase 17B (STK17B).
PDB Id:  3LM0
Resolution:  2.35Å
Species:  Human
References: 
Enzyme Reaction
EC Number: 2.7.11.1
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: DRAK2
Ligand Sp. Type Action Affinity Units
KW-2449 Hs Inhibitor Inhibition 8.3 pKd
lestaurtinib Hs Inhibitor Inhibition 8.3 pKd
MLN-8054 Hs Inhibitor Inhibition 8.1 pKd
tamatinib Hs Inhibitor Inhibition 8.0 pKd
staurosporine Hs Inhibitor Inhibition 7.7 pKd
fedratinib Hs Inhibitor Inhibition 7.3 pKd
sunitinib Hs Inhibitor Inhibition 7.0 pKd
SU-14813 Hs Inhibitor Inhibition 6.5 pKd
neratinib Hs Inhibitor Inhibition 6.0 pKd
dovitinib Hs Inhibitor Inhibition 5.7 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

Death-associated kinase (DAPK) family: serine/threonine kinase 17b. Last modified on 26/03/2013. Accessed on 13/12/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2215.