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serine/threonine kinase 36

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Target not currently curated in GtoImmuPdb

Target id: 2223

Nomenclature: serine/threonine kinase 36

Abbreviated Name: Fused

Family: Unc-51-like kinase (ULK) family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1315 2q35 STK36 serine/threonine kinase 36
Mouse - 1316 1 C3 Stk36 serine/threonine kinase 36
Rat - 1314 9 q33 Stk36 serine/threonine kinase 36
Previous and Unofficial Names Click here for help
FU
Database Links Click here for help
Alphafold Q9NRP7 (Hs), Q69ZM6 (Mm)
BRENDA 2.7.11.1
CATH/Gene3D 1.25.10.10
ChEMBL Target CHEMBL4312 (Hs)
Ensembl Gene ENSG00000163482 (Hs), ENSMUSG00000033276 (Mm), ENSRNOG00000016913 (Rn)
Entrez Gene 27148 (Hs), 269209 (Mm), 301516 (Rn)
Human Protein Atlas ENSG00000163482 (Hs)
KEGG Enzyme 2.7.11.1
KEGG Gene hsa:27148 (Hs), mmu:269209 (Mm), rno:301516 (Rn)
OMIM 607652 (Hs)
Pharos Q9NRP7 (Hs)
RefSeq Nucleotide NM_001243313 (Hs), NM_175031 (Mm), NM_001173986 (Rn)
RefSeq Protein NP_056505 (Hs), NP_778196 (Mm), NP_001167457 (Rn)
UniProtKB Q9NRP7 (Hs), Q69ZM6 (Mm)
Wikipedia STK36 (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.1

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
Ro-0505124 Small molecule or natural product Click here for species-specific activity table Hs Inhibition - - 1
⤷ [1]
Description: Measured as % inhibition using 1μM compound.
Inhibitor Comments
Ro-0505124 inhibits STK36 kinase activity by 86% at 1μM [1].
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 2-3
Key to terms and symbols Click column headers to sort
Target used in screen: STK36
Ligand Sp. Type Action Value Parameter
foretinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.7 pKd
dasatinib Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.7 pKd
tamatinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.6 pKd
BMS-387032 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.6 pKd
PD-173955 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.5 pKd
pazopanib Small molecule or natural product Approved drug Hs Inhibitor Inhibition 6.3 pKd
bosutinib Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.2 pKd
fedratinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 6.1 pKd
SB203580 Small molecule or natural product Immunopharmacology Ligand Hs Inhibitor Inhibition 5.9 pKd
AST-487 Small molecule or natural product Hs Inhibitor Inhibition 5.9 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Burgess A, Wigan M, Giles N, Depinto W, Gillespie P, Stevens F, Gabrielli B. (2006) Inhibition of S/G2 phase CDK4 reduces mitotic fidelity. J Biol Chem, 281 (15): 9987-95. [PMID:16476733]

2. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

3. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

Unc-51-like kinase (ULK) family: serine/threonine kinase 36. Last modified on 24/02/2015. Accessed on 20/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2223.