Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	358	22q11.21	TSSK2	testis specific serine kinase 2
Mouse	-	358	16 11.09 cM	Tssk2	testis-specific serine kinase 2
Rat	-	358	11 q23	Tssk2	testis-specific serine kinase 2

Previous and Unofficial Names

serine/threonine kinase 22B (spermiogenesis associated) | SPOGA2 | STK22B | Tsk2

Database Links
Alphafold	Q96PF2 (Hs), O54863 (Mm)
BRENDA	2.7.11.1
ChEMBL Target	CHEMBL6014 (Hs)
Ensembl Gene	ENSG00000206203 (Hs), ENSMUSG00000045521 (Mm), ENSRNOG00000037997 (Rn)
Entrez Gene	23617 (Hs), 22115 (Mm), 304181 (Rn)
Human Protein Atlas	ENSG00000206203 (Hs)
KEGG Enzyme	2.7.11.1
KEGG Gene	hsa:23617 (Hs), mmu:22115 (Mm), rno:304181 (Rn)
OMIM	610710 (Hs)
Pharos	Q96PF2 (Hs)
RefSeq Nucleotide	NM_053006 (Hs), NM_009436 (Mm), NM_001012019 (Rn)
RefSeq Protein	NP_443732 (Hs), NP_033462 (Mm), NP_001012019 (Rn)
UniProtKB	Q96PF2 (Hs), O54863 (Mm)
Wikipedia	TSSK2 (Hs)

Enzyme Reaction
EC Number: 2.7.11.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 2c [PMID: 24900538] Hs Inhibition 7.5 pIC50 3 ⤷ pIC50 7.5 (IC50 3.06x10-8 M) [3]

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: 1-2
Key to terms and symbols		Click column headers to sort
Target used in screen: TSSK2/TSSK2
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM staurosporine Hs Inhibitor Inhibition 1.2 -0.5 0.5 K-252a Hs Inhibitor Inhibition 16.6 8.0 0.0 SU11652 Hs Inhibitor Inhibition 66.9 62.0 26.0 sunitinib Hs Inhibitor Inhibition 72.9 nilotinib Hs Inhibitor Inhibition 73.5 Gö 6976 Hs Inhibitor Inhibition 74.3 64.0 40.0 PDK1/Akt/Flt dual pathway inhibitor Hs Inhibitor Inhibition 75.0 97.0 100.0 PDGF receptor tyrosine kinase inhibitor IV Hs Inhibitor Inhibition 75.1 85.0 97.0 PDGF receptor tyrosine kinase inhibitor II Hs Inhibitor Inhibition 78.0 96.0 96.0 p38 MAP kinase inhibitor III Hs Inhibitor Inhibition 78.2 98.0 101.0
Displaying the top 10 most potent ligands  View all ligands in screen »