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tau tubulin kinase 1

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Target not currently curated in GtoImmuPdb

Target id: 2262

Nomenclature: tau tubulin kinase 1

Abbreviated Name: TTBK1

Family: Tau tubulin kinase (TTBK) family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1321 6p21.1 TTBK1 tau tubulin kinase 1
Mouse - 1308 17 C Ttbk1 tau tubulin kinase 1
Rat - 1307 9q12 Ttbk1 tau tubulin kinase 1
Database Links Click here for help
Alphafold Q5TCY1 (Hs), Q6PCN3 (Mm), D3ZAU7 (Rn)
BRENDA 2.7.11.1
CATH/Gene3D 1.25.10.10
ChEMBL Target CHEMBL1926492 (Hs)
Ensembl Gene ENSG00000146216 (Hs), ENSMUSG00000015599 (Mm), ENSRNOG00000018416 (Rn)
Entrez Gene 84630 (Hs), 106763 (Mm), 316229 (Rn)
Human Protein Atlas ENSG00000146216 (Hs)
KEGG Enzyme 2.7.11.1
KEGG Gene hsa:84630 (Hs), mmu:106763 (Mm), rno:316229 (Rn)
Pharos Q5TCY1 (Hs)
RefSeq Nucleotide NM_032538 (Hs), NM_001162864 (Mm), NM_001271230 (Rn)
RefSeq Protein NP_115927 (Hs), NP_001156336 (Mm), NP_001258159 (Rn)
UniProtKB Q5TCY1 (Hs), Q6PCN3 (Mm), D3ZAU7 (Rn)
Wikipedia TTBK1 (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Structure of TTBK1 kinase domain in complex with Compound 3 (AMG28)
PDB Id:  7JXX
Ligand:  AMG28
Resolution:  1.56Å
Species:  Human
References:  1
Enzyme Reaction Click here for help
EC Number: 2.7.11.1

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
AMG28 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 6.7 pIC50 1
⤷ pIC50 6.7 (IC50 1.99x10-7 M) [1]
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Immune regulation
Immuno Process:  Cellular signalling

References

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1. Halkina T, Henderson JL, Lin EY, Himmelbauer MK, Jones JH, Nevalainen M, Feng J, King K, Rooney M, Johnson JL et al.. (2021) Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo. J Med Chem, 64 (9): 6358-6380. [PMID:33944571]

How to cite this page

Tau tubulin kinase (TTBK) family: tau tubulin kinase 1. Last modified on 20/09/2022. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2262.