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twinfilin actin binding protein 1

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Target not currently curated in GtoImmuPdb

Target id: 2266

Nomenclature: twinfilin actin binding protein 1

Abbreviated Name: A6

Family: Twinfilin subfamily

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 350 12q12 TWF1 twinfilin actin binding protein 1
Mouse - 350 15 E3 Twf1 twinfilin actin binding protein 1
Rat - 350 7q35 Twf1 twinfilin actin-binding protein 1
Previous and Unofficial Names Click here for help
actin monomer-binding protein | protein tyrosine kinase 9 | PTK9 | twinfilin actin-binding protein 1
Database Links Click here for help
Alphafold Q12792 (Hs), Q91YR1 (Mm), Q5RJR2 (Rn)
CATH/Gene3D 3.40.20.10
Ensembl Gene ENSG00000151239 (Hs), ENSMUSG00000022451 (Mm), ENSRNOG00000022507 (Rn)
Entrez Gene 5756 (Hs), 19230 (Mm), 315265 (Rn)
Human Protein Atlas ENSG00000151239 (Hs)
KEGG Gene hsa:5756 (Hs), mmu:19230 (Mm), rno:315265 (Rn)
OMIM 610932 (Hs)
Pharos Q12792 (Hs)
RefSeq Nucleotide NM_001242397 (Hs), NM_008971 (Mm), NM_001008521 (Rn)
RefSeq Protein NP_002813 (Hs), NP_032997 (Mm), NP_001008521 (Rn)
UniProtKB Q12792 (Hs), Q91YR1 (Mm), Q5RJR2 (Rn)
Wikipedia TWF1 (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of the N-terminal ADF-H domain of the mouse Twiflin isoform-1.
PDB Id:  1M4J
Resolution:  1.6Å
Species:  Mouse
References:  2
Image of receptor 3D structure from RCSB PDB
Description:  Solution structure of C-teminal domain of twinfilin-1.
PDB Id:  2HD7
Resolution:  0.0Å
Species:  Mouse
References:  1

References

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1. Paavilainen VO, Hellman M, Helfer E, Bovellan M, Annila A, Carlier MF, Permi P, Lappalainen P. (2007) Structural basis and evolutionary origin of actin filament capping by twinfilin. Proc Natl Acad Sci USA, 104 (9): 3113-8. [PMID:17360616]

2. Paavilainen VO, Merckel MC, Falck S, Ojala PJ, Pohl E, Wilmanns M, Lappalainen P. (2002) Structural conservation between the actin monomer-binding sites of twinfilin and actin-depolymerizing factor (ADF)/cofilin. J Biol Chem, 277 (45): 43089-95. [PMID:12207032]

How to cite this page

Twinfilin subfamily: twinfilin actin binding protein 1. Last modified on 30/07/2015. Accessed on 18/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2266.