Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	2297	9q22.31	WNK2	WNK lysine deficient protein kinase 2
Mouse	-	2149	13 25.07 cM	Wnk2	WNK lysine deficient protein kinase 2
Rat	-	2063	17p14	Wnk2	WNK lysine deficient protein kinase 2

Previous and Unofficial Names

SDCCAG43, PRKWNK2 | serologically defined colon cancer antigen 43

Database Links
Alphafold	Q9Y3S1 (Hs), Q3UH66 (Mm)
BRENDA	2.7.11.1
ChEMBL Target	CHEMBL5639 (Hs)
Ensembl Gene	ENSG00000165238 (Hs), ENSMUSG00000037989 (Mm), ENSRNOG00000016684 (Rn)
Entrez Gene	65268 (Hs), 75607 (Mm), 306811 (Rn)
Human Protein Atlas	ENSG00000165238 (Hs)
KEGG Enzyme	2.7.11.1
KEGG Gene	hsa:65268 (Hs), mmu:75607 (Mm), rno:306811 (Rn)
OMIM	606249 (Hs)
Pharos	Q9Y3S1 (Hs)
RefSeq Nucleotide	NM_006648 (Hs), NM_029361 (Mm), NM_001191556 (Rn)
RefSeq Protein	NP_006639 (Hs), NP_083637 (Mm), NP_001178485 (Rn)
UniProtKB	Q9Y3S1 (Hs), Q3UH66 (Mm)
Wikipedia	WNK2 (Hs)

Enzyme Reaction
EC Number: 2.7.11.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 25 [PMID: 17935989] Hs Inhibition <5.8 pKi 3 ⤷ pKi <5.8 (Ki >1.518x10-6 M) [3]

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: 1-2
Key to terms and symbols		Click column headers to sort
Target used in screen: WNK2/WNK2
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM TGF-beta RI kinase inhibitor Hs Inhibitor Inhibition 49.2 105.0 88.0 GSK-3 inhibitor XIII Hs Inhibitor Inhibition 82.6 74.0 27.0 dasatinib Hs Inhibitor Inhibition 83.9 indirubin derivative E804 Hs Inhibitor Inhibition 85.4 71.0 40.0 isogranulatimide Hs Inhibitor Inhibition 86.6 82.0 43.0 Src kinase inhibitor I Hs Inhibitor Inhibition 88.1 92.0 41.0 Cdk2 inhibitor IV Hs Inhibitor Inhibition 88.6 96.0 48.0 BPIQ-I Hs Inhibitor Inhibition 89.7 105.0 85.0 Cdk4 inhibitor II Hs Inhibitor Inhibition 89.8 86.0 87.0 bohemine Hs Inhibitor Inhibition 90.5 98.0 89.0
Displaying the top 10 most potent ligands  View all ligands in screen »