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serine/threonine-protein kinase NIM1

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Target not currently curated in GtoImmuPdb

Target id: 2291

Nomenclature: serine/threonine-protein kinase NIM1

Abbreviated Name: NIM1

Family: NIM1 subfamily

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 436 5p12 NIM1K NIM1 serine/threonine protein kinase
Mouse - 436 13 D2.3 Nim1k NIM1 serine/threonine protein kinase
Rat - 436 2q16 Nim1k NIM1 serine/threonine protein kinase
Database Links Click here for help
Alphafold Q8IY84 (Hs), Q8BHI9 (Mm)
BRENDA 2.7.11.1
ChEMBL Target CHEMBL3542 (Hs)
Ensembl Gene ENSG00000177453 (Hs), ENSMUSG00000095930 (Mm), ENSRNOG00000016353 (Rn)
Entrez Gene 167359 (Hs), 245269 (Mm), 310376 (Rn)
Human Protein Atlas ENSG00000177453 (Hs)
KEGG Enzyme 2.7.11.1
KEGG Gene hsa:167359 (Hs), mmu:245269 (Mm), rno:310376 (Rn)
Pharos Q8IY84 (Hs)
RefSeq Nucleotide NM_153361 (Hs), NM_175538 (Mm), XM_227081 (Rn)
RefSeq Protein NP_699192 (Hs), NP_780747 (Mm), XP_227081 (Rn)
UniProtKB Q8IY84 (Hs), Q8BHI9 (Mm)
Wikipedia NIM1K (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.1

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 89S [PMID: 19115845] Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition <5.4 pIC50 2
⤷ pIC50 <5.4 (IC50 >4x10-6 M) [2]
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1,3
Key to terms and symbols Click column headers to sort
Target used in screen: NIM1
Ligand Sp. Type Action Value Parameter
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.8 pKd
tamatinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.2 pKd
BI-2536 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.1 pKd
sunitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 6.1 pKd
dovitinib Small molecule or natural product Hs Inhibitor Inhibition 6.1 pKd
SU-14813 Small molecule or natural product Hs Inhibitor Inhibition 6.0 pKd
KW-2449 Small molecule or natural product Hs Inhibitor Inhibition 6.0 pKd
bosutinib Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 5.8 pKd
lestaurtinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 5.7 pKd
NVP-TAE684 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 5.6 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Menichincheri M, Bargiotti A, Berthelsen J, Bertrand JA, Bossi R, Ciavolella A, Cirla A, Cristiani C, Croci V, D'Alessio R et al.. (2009) First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. J Med Chem, 52 (2): 293-307. [PMID:19115845]

3. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

NIM1 subfamily: serine/threonine-protein kinase NIM1. Last modified on 17/09/2015. Accessed on 18/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2291.