Interleukin-15 receptor

Target id: 2302

Nomenclature: Interleukin-15 receptor

Family: IL-2 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin-15 receptor has curated GtoImmuPdb data

Quaternary Structure: Subunits
Interleukin-2 receptor subunit β (Ligand-binding subunit)
Interleukin-15 receptor subunit α (Ligand-binding subunit)
Interleukin-2 receptor subunit γ (Other subunit)

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Agonists
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Ligand Sp. Action Affinity Units Reference
ALT-803 Hs Agonist ~12.3 pIC50 2
pIC50 ~12.3 (IC50 ~5x10-13 M) [2]
Description: Binding of rhIL-15N72D to hIL-15R in vitro.
IL-15 {Sp: Human} Hs Agonist 11.4 pIC50 2
pIC50 11.4 (IC50 3.8x10-12 M) [2]
Description: Binding of rhIL-15 in vitro, using cells expressing the intact hIL-15Rα-hIL-15Rβ-hγ complex.
Immunopharmacology Comments
The functional IL-15 receptor is a heteromer consisting of the high affinity ligand binding interleukin-15 receptor subunit α (IL15RA) and common IL-2-γ and -β signal transducing subunits (IL2RG and IL2RB) [1].

References

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1. Anderson DM, Kumaki S, Ahdieh M, Bertles J, Tometsko M, Loomis A, Giri J, Copeland NG, Gilbert DJ, Jenkins NA et al.. (1995) Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes. J. Biol. Chem.270 (50): 29862-9. [PMID:8530383]

2. Zhu X, Marcus WD, Xu W, Lee HI, Han K, Egan JO, Yovandich JL, Rhode PR, Wong HC. (2009) Novel human interleukin-15 agonists. J. Immunol.183 (6): 3598-607. [PMID:19710453]

How to cite this page

IL-2 receptor family: Interleukin-15 receptor. Last modified on 31/07/2017. Accessed on 17/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2302.