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| Quaternary Structure: Subunits |
| Interleukin-31 receptor, α subunit (Ligand-binding subunit) |
| Oncostatin M-specific receptor, β subunit (Other subunit) |
Natural/Endogenous Ligands  |
| IL-31 {Sp: Human} |
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| Immunopharmacology Comments |
| The IL-31 receptor is a type I cytokine receptor expressed on monocytes [3]. The α subunit (IL31RA) can bind ligand as a monomer or as a partner in a heterodimeric complex with the oncostatin M-specific receptor β subunit (OSMR). Ligand binding to the IL-31 receptor leads to activation of the STAT and ERK1/2 pathways [1-2]. The IL-31/IL-31 receptor pathway is involved in pruritus. |
1. Dillon SR, Sprecher C, Hammond A, Bilsborough J, Rosenfeld-Franklin M, Presnell SR, Haugen HS, Maurer M, Harder B, Johnston J et al.. (2004) Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Nat Immunol, 5 (7): 752-60. [PMID:15184896]
2. Kasraie S, Niebuhr M, Werfel T. (2013) Interleukin (IL)-31 activates signal transducer and activator of transcription (STAT)-1, STAT-5 and extracellular signal-regulated kinase 1/2 and down-regulates IL-12p40 production in activated human macrophages. Allergy, 68 (6): 739-47. [PMID:23621408]
3. Kato A, Fujii E, Watanabe T, Takashima Y, Matsushita H, Furuhashi T, Morita A. (2014) Distribution of IL-31 and its receptor expressing cells in skin of atopic dermatitis. J Dermatol Sci, 74 (3): 229-35. [PMID:24667097]
IL-6 receptor family: Interleukin-31 receptor. Last modified on 07/04/2017. Accessed on 18/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2312.
target has curated data in GtoImmuPdb
