Interleukin-6 receptor, β subunit

Target id: 2317

Nomenclature: Interleukin-6 receptor, β subunit

Abbreviated Name: IL6ST

Systematic Nomenclature: interleukin 6 signal transducer

Family: IL-6 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin-6 receptor, β subunit has curated GtoImmuPdb data

Quaternary Structure: Complexes
Interleukin-6 receptor
Interleukin-11 receptor
Ciliary neutrophic factor receptor
Leukemia inhibitory factor receptor
Oncostatin-M receptor
Interleukin-27 receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 918 5q11.2 IL6ST interleukin 6 signal transducer
Mouse 1 917 13 63.73 cM Il6st interleukin 6 signal transducer
Rat 1 918 2q14-q16 Il6st interleukin 6 signal transducer
Previous and Unofficial Names
CD130 | gp130 | interleukin-6 receptor subunit beta | membrane glycoprotein 130 | oncostatin-M receptor subunit alpha | interleukin 6 signal transducer (gp130, oncostatin M receptor)
Database Links
CATH/Gene3D
Ensembl Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
OMIM
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Cytokine-binding region of gp130
PDB Id:  1BQU
Resolution:  2.0Å
Species:  Human
References:  1
Immunopharmacology Comments
This is the common signal transducing subunit shared by members of the IL-6 family of cytokine receptors.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of acute inflammatory response (GO:0002675) IC
References: 
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of adaptive immune response (GO:0002821) IC
positive regulation of T cell proliferation (GO:0042102) IMP
References: 
Immuno Process:  B cell (activation)
Immuno Process ID:  5
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of adaptive immune response (GO:0002821) IC
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of acute inflammatory response (GO:0002675) IC
positive regulation of adaptive immune response (GO:0002821) IC
positive regulation of T cell proliferation (GO:0042102) IMP
References: 
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  ciliary neurotrophic factor receptor activity (GO:0004897) IDA
interleukin-11 receptor activity (GO:0004921) IEA
positive regulation of vascular endothelial growth factor production (GO:0010575) TAS
cytokine-mediated signaling pathway (GO:0019221) IDA
response to cytokine (GO:0034097) IDA
oncostatin-M-mediated signaling pathway (GO:0038165) IMP
interleukin-27 receptor activity (GO:0045509) IC
interleukin-6-mediated signaling pathway (GO:0070102) IMP
negative regulation of interleukin-6-mediated signaling pathway (GO:0070104) IDA
interleukin-27-mediated signaling pathway (GO:0070106) IMP
ciliary neurotrophic factor-mediated signaling pathway (GO:0070120) IDA
References: 
Immuno Process:  Chemotaxis & migration
Immuno Process ID:  10
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of T cell proliferation (GO:0042102) IMP
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of T cell proliferation (GO:0042102) IMP
References: 

References

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1. Bravo J, Staunton D, Heath JK, Jones EY. (1998) Crystal structure of a cytokine-binding region of gp130. EMBO J.17 (6): 1665-74. [PMID:9501088]

How to cite this page

IL-6 receptor family: Interleukin-6 receptor, β subunit. Last modified on 07/04/2017. Accessed on 22/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2317.