Interleukin 27 receptor, alpha

Target id: 2318

Nomenclature: Interleukin 27 receptor, alpha

Family: IL-6 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin 27 receptor, alpha has curated GtoImmuPdb data

Quaternary Structure: Complexes
Interleukin-27 receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 636 19p13.12 IL27RA interleukin 27 receptor subunit alpha
Mouse 1 623 8 C3 Il27ra interleukin 27 receptor
Rat - - 19q11 Il27ra interleukin 27 receptor subunit alpha
Previous and Unofficial Names
WSX-1 | cytokine receptor-like 1 | IL-27RA | TCCR | interleukin 27 receptor, alpha
Database Links
CATH/Gene3D
Ensembl Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
UniProtKB
Wikipedia
Immunopharmacology Comments
This is the ligand binding subunit of the IL-27 receptor heterodimer, a complex with IL6ST (signal transducing subunit).
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  regulation of isotype switching to IgG isotypes (GO:0048302) IEA
References: 
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of T-helper 1 type immune response (GO:0002827) IEA
regulation of isotype switching to IgG isotypes (GO:0048302) IEA
References: 
Immuno Process:  B cell (activation)
Immuno Process ID:  5
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of T-helper 1 type immune response (GO:0002827) IEA
regulation of isotype switching to IgG isotypes (GO:0048302) IEA
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of T-helper 1 type immune response (GO:0002827) IEA
negative regulation of type 2 immune response (GO:0002829) IEA
regulation of isotype switching to IgG isotypes (GO:0048302) IEA
References: 
Immuno Process:  Immune system development
Immuno Process ID:  8
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  regulation of isotype switching to IgG isotypes (GO:0048302) IEA
References: 
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of interferon-gamma production (GO:0032729) IEA
interleukin-12-mediated signaling pathway (GO:0035722) TAS
interleukin-27 receptor activity (GO:0045509) IEA
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  regulation of isotype switching to IgG isotypes (GO:0048302) IEA
References: 
Physiological Consequences of Altering Gene Expression
MIce lacking Il27ra expression by their Treg cells develop more severe experimental autoimmune encephalomyelitis (EAE) than wild type mice, indicating that IL-27 is important for Treg function and control of autoimmunity.
Species:  Mouse
Tissue:  T regulatory cells.
Technique: 
References:  1

References

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1. Do J, Kim D, Kim S, Valentin-Torres A, Dvorina N, Jang E, Nagarajavel V, DeSilva TM, Li X, Ting AH et al.. (2017) Treg-specific IL-27Rα deletion uncovers a key role for IL-27 in Treg function to control autoimmunity. Proc. Natl. Acad. Sci. U.S.A.,  [Epub ahead of print]. [PMID:28874534]

How to cite this page

IL-6 receptor family: Interleukin 27 receptor, alpha. Last modified on 18/09/2017. Accessed on 12/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2318.