Interleukin 27 receptor, alpha

Target id: 2318

Nomenclature: Interleukin 27 receptor, alpha

Family: IL-6 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin 27 receptor, alpha has curated GtoImmuPdb data

Quaternary Structure: Complexes
Interleukin-27 receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 636 19p13.12 IL27RA interleukin 27 receptor subunit alpha
Mouse 1 623 8 C3 Il27ra interleukin 27 receptor, alpha
Rat - - 19q11 Il27ra interleukin 27 receptor subunit alpha
Previous and Unofficial Names
WSX-1 | cytokine receptor-like 1 | IL-27RA | TCCR | interleukin 27 receptor, alpha
Database Links
CATH/Gene3D
Ensembl Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
UniProtKB
Wikipedia
Immunopharmacology Comments
This is the ligand binding subunit of the IL-27 receptor heterodimer, a complex with IL6ST (signal transducing subunit).
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  regulation of isotype switching to IgG isotypes (GO:0048302) IEA
References: 
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of T-helper 1 type immune response (GO:0002827) IEA
regulation of isotype switching to IgG isotypes (GO:0048302) IEA
References: 
Immuno Process:  B cell (activation)
Immuno Process ID:  5
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of T-helper 1 type immune response (GO:0002827) IEA
regulation of isotype switching to IgG isotypes (GO:0048302) IEA
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of T-helper 1 type immune response (GO:0002827) IEA
negative regulation of type 2 immune response (GO:0002829) IEA
regulation of isotype switching to IgG isotypes (GO:0048302) IEA
References: 
Immuno Process:  Immune system development
Immuno Process ID:  8
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  regulation of isotype switching to IgG isotypes (GO:0048302) IEA
References: 
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of interferon-gamma production (GO:0032729) IEA
interleukin-27 receptor activity (GO:0045509) IEA
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  regulation of isotype switching to IgG isotypes (GO:0048302) IEA
References: 

How to cite this page

IL-6 receptor family: Interleukin 27 receptor, alpha. Last modified on 07/04/2017. Accessed on 18/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2318.