Interleukin 27 receptor, alpha

Target id: 2318

Nomenclature: Interleukin 27 receptor, alpha

Family: IL-6 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin 27 receptor, alpha has curated GtoImmuPdb data

Quaternary Structure: Complexes
Interleukin-27 receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 636 19p13.12 IL27RA interleukin 27 receptor subunit alpha
Mouse 1 623 8 C3 Il27ra interleukin 27 receptor, alpha
Rat - - 19q11 Il27ra interleukin 27 receptor subunit alpha
Previous and Unofficial Names
WSX-1 | cytokine receptor-like 1 | IL-27RA | TCCR | interleukin 27 receptor, alpha | interleukin 27 receptor
Database Links
CATH/Gene3D
Ensembl Gene
Human Protein Atlas
UniProtKB
Wikipedia
Immunopharmacology Comments
This is the ligand binding subunit of the IL-27 receptor heterodimer, a complex with IL6ST (signal transducing subunit).
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0048302 regulation of isotype switching to IgG isotypes IEA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 2 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0002827 positive regulation of T-helper 1 type immune response IEA
GO:0048302 regulation of isotype switching to IgG isotypes IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 2 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0002827 positive regulation of T-helper 1 type immune response IEA
GO:0048302 regulation of isotype switching to IgG isotypes IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0002827 positive regulation of T-helper 1 type immune response IEA
GO:0002829 negative regulation of type 2 immune response IEA
GO:0048302 regulation of isotype switching to IgG isotypes IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0048302 regulation of isotype switching to IgG isotypes IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 3 GO processes, IEA only
GO:0035722 interleukin-12-mediated signaling pathway TAS
click arrow to show/hide IEA associations
GO:0032729 positive regulation of interferon-gamma production IEA
GO:0045509 interleukin-27 receptor activity IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0048302 regulation of isotype switching to IgG isotypes IEA
Physiological Consequences of Altering Gene Expression
MIce lacking Il27ra expression by their Treg cells develop more severe experimental autoimmune encephalomyelitis (EAE) than wild type mice, indicating that IL-27 is important for Treg function and control of autoimmunity.
Species:  Mouse
Tissue:  T regulatory cells.
Technique: 
References:  1

References

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1. Do J, Kim D, Kim S, Valentin-Torres A, Dvorina N, Jang E, Nagarajavel V, DeSilva TM, Li X, Ting AH et al.. (2017) Treg-specific IL-27Rα deletion uncovers a key role for IL-27 in Treg function to control autoimmunity. Proc. Natl. Acad. Sci. U.S.A., 114 (38): 10190-10195. [PMID:28874534]

How to cite this page

IL-6 receptor family: Interleukin 27 receptor, alpha. Last modified on 18/09/2017. Accessed on 23/06/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2318.