Interleukin-1 receptor, type II

Target id: 2321

Nomenclature: Interleukin-1 receptor, type II

Family: Immunoglobulin-like family of IL-1 receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin-1 receptor, type II has curated GtoImmuPdb data

Quaternary Structure: Subunits
Interleukin 1 receptor, type II (Ligand-binding subunit)
IL-1 receptor accessory protein (Other subunit)
Immunopharmacology Comments
Interleukin-1 receptor, type II (IL-1RII) is a heterodimer containing the ligand binding interleukin 1 receptor, type II (IL1R2) subunit and the IL-1 receptor accessory protein (IL1RAP). Unlike IL-1RI, IL-1RII is unable to transduce a signal in response to ligand binding, acting instead as a decoy receptor for its ligands IL-1α, IL-1β.

How to cite this page

Immunoglobulin-like family of IL-1 receptors: Interleukin-1 receptor, type II. Last modified on 21/03/2017. Accessed on 23/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2321.