complement C1r

Target id: 2334

Nomenclature: complement C1r

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     complement C1r has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 705 12p13.31 C1R complement C1r
Mouse - 707 6 F2 C1ra complement component 1
Rat - 707 4q42 C1r complement C1r
Previous and Unofficial Names
complement C1r-A subcomponent | complement component 1, r subcomponent A
Database Links
Specialist databases
MEROPS S01.192 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.21.41

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
nafamostat Hs Inhibition 4.9 pIC50 1
pIC50 4.9 (IC50 1.2x10-5 M) [1]
Immunopharmacology Comments
A protease component of the C1-complex of the classical complement pathway.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  regulation of complement activation (GO:0030449) TAS
innate immune response (GO:0045087) IEA
References: 
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  complement activation, classical pathway (GO:0006958) TAS
References: 
Immuno Process:  B cell (activation)
Immuno Process ID:  5
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  complement activation, classical pathway (GO:0006958) TAS
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  complement activation (GO:0006956) TAS
complement activation, classical pathway (GO:0006958) TAS
regulation of complement activation (GO:0030449) TAS
References: 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Complement component C1r/C1s deficiency
Synonyms: Immunodeficiency due to an early component of complement deficiency [Orphanet: ORPHA169147]
OMIM: 216950
Orphanet: ORPHA169147

References

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1. Hays SJ, Caprathe BW, Gilmore JL, Amin N, Emmerling MR, Michael W, Nadimpalli R, Nath R, Raser KJ, Stafford D et al.. (1998) 2-amino-4H-3,1-benzoxazin-4-ones as inhibitors of C1r serine protease. J. Med. Chem.41 (7): 1060-7. [PMID:9544206]

How to cite this page

S1: Chymotrypsin: complement C1r. Last modified on 17/02/2017. Accessed on 12/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2334.