complement C1s

Target id: 2335

Nomenclature: complement C1s

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     complement C1s has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 688 12p13 C1S complement C1s
Mouse - 688 6 F2 C1s2 complement component 1, s subcomponent 2
Rat - 694 4q42 C1s complement C1s
Previous and Unofficial Names
C1sb | complement component C1SB | r-gsp | Gm5077 | predicted gene 5077 | complement component 1 | complement component 1, s subcomponent 2
Database Links
Specialist databases
MEROPS S01.193 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.21.42

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 28 [PMID: 16460935] Hs Inhibition 8.0 pKi 2
pKi 8.0 (Ki 1x10-8 M) [2]
Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
TNT009 Hs Binding 9.6 pKd 1
pKd 9.6 (Kd 2.6x10-10 M) [1]
Antibody Comments
TNT009 binds to pro-C1s and mature C1s with the same affinity [1].
Immunopharmacology Comments
A protease component of the C1-complex of the classical complement pathway.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes
GO:0001867 complement activation, lectin pathway IBA
GO:0030449 regulation of complement activation TAS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0006958 complement activation, classical pathway TAS
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0006958 complement activation, classical pathway TAS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 4 GO processes
GO:0001867 complement activation, lectin pathway IBA
GO:0006956 complement activation TAS
GO:0006958 complement activation, classical pathway TAS
GO:0030449 regulation of complement activation TAS
Clinically-Relevant Mutations and Pathophysiology
Disease:  Complement component C1s deficiency
Synonyms: Immunodeficiency due to an early component of complement deficiency [Orphanet: ORPHA169147]
OMIM: 613783
Orphanet: ORPHA169147

References

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1. Panicker S, Parry G. (2016) Humanized anti-c1s antibodies and methods of use thereof. Patent number: WO2016164358A1. Assignee: True North Therapeutics, Inc.. Priority date: 06/04/2015. Publication date: 05/04/2016.

2. Subasinghe NL, Travins JM, Ali F, Huang H, Ballentine SK, Marugán JJ, Khalil E, Hufnagel HR, Bone RF, DesJarlais RL et al.. (2006) A novel series of arylsulfonylthiophene-2-carboxamidine inhibitors of the complement component C1s. Bioorg. Med. Chem. Lett.16 (8): 2200-4. [PMID:16460935]

How to cite this page

S1: Chymotrypsin: complement C1s. Last modified on 15/02/2018. Accessed on 20/04/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2335.