cathepsin D

Target id: 2345

Nomenclature: cathepsin D

Family: A1: Pepsin

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for cathepsin D in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 412 11p15.5 CTSD cathepsin D
Mouse - 410 7 F5 Ctsd cathepsin D
Rat - 407 1q41 Ctsd cathepsin D
Previous and Unofficial Names
CatD | CD | ceroid-lipofuscinosis, neuronal 10 | CLN10 | CPSD
Database Links
Specialist databases
MEROPS A01.009 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.23.5

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 3 [PMID: 8410973] Hs Inhibition 7.7 pKi 3
pKi 7.7 (Ki 1.8x10-8 M) [3]
compound 1 [PMID: 10498202] Hs Inhibition 9.2 pIC50 1
pIC50 9.2 (IC50 7x10-10 M) [1]
grassystatin A Hs Inhibition 7.6 pIC50 2
pIC50 7.6 (IC50 2.65x10-8 M) [2]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Ceroid lipofuscinosis, neuronal, 10
Synonyms: Cathepsin D deficiency
CLN10 disease [Orphanet: ORPHA228337]
Neuronal ceroid lipofuscinosis [Disease Ontology: DOID:14503]
Disease Ontology: DOID:14503
OMIM: 610127
Orphanet: ORPHA228337

References

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1. Dumas J, Brittelli D, Chen J, Dixon B, Hatoum-Mokdad H, König G, Sibley R, Witowsky J, Wong S. (1999) Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors. Bioorg. Med. Chem. Lett.9 (17): 2531-6. [PMID:10498202]

2. Kwan JC, Eksioglu EA, Liu C, Paul VJ, Luesch H. (2009) Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J. Med. Chem.52 (18): 5732-47. [PMID:19715320]

3. Rao CM, Scarborough PE, Kay J, Batley B, Rapundalo S, Klutchko S, Taylor MD, Lunney EA, Humblet CC, Dunn BM. (1993) Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation. J. Med. Chem.36 (18): 2614-20. [PMID:8410973]

How to cite this page

A1: Pepsin: cathepsin D. Last modified on 29/07/2015. Accessed on 13/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2345.