cathepsin Z | C1: Papain | IUPHAR/BPS Guide to PHARMACOLOGY

cathepsin Z

Target id: 2354

Nomenclature: cathepsin Z

Family: C1: Papain

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for cathepsin Z in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 303 20q13.32 CTSZ cathepsin Z
Mouse - 306 2 H4 Ctsz cathepsin Z
Rat - 306 3 Ctsz cathepsin Z
Previous and Unofficial Names
carboxypeptidase LB | cathepsin B2 | cathepsin IV | cathepsin Y | lysosomal carboxypeptidase B | cathepsin X | CATX | CTSX | cysteine-type carboxypeptidase
Database Links
Specialist databases
MEROPS C01.013 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.18.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
odanacatib Hs Inhibition 8.0 pIC50 1
pIC50 8.0 (IC50 1x10-8 M) [1]

References

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1. Gauthier JY, Chauret N, Cromlish W, Desmarais S, Duong le T, Falgueyret JP, Kimmel DB, Lamontagne S, Léger S, LeRiche T et al.. (2008) The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. Bioorg. Med. Chem. Lett., 18 (3): 923-8. [PMID:18226527]

How to cite this page

C1: Papain: cathepsin Z. Last modified on 28/07/2015. Accessed on 18/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2354.