Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	303	20q13.32	CTSZ	cathepsin Z
Mouse	-	306	2 97.94 cM	Ctsz	cathepsin Z
Rat	-	306	3q43	Ctsz	cathepsin Z

Previous and Unofficial Names

carboxypeptidase LB | cathepsin B2 | cathepsin IV | cathepsin Y | lysosomal carboxypeptidase B | cathepsin X | CATX | CTSX | cysteine-type carboxypeptidase

Database Links
Specialist databases
MEROPS	C01.013 (Hs)
Other databases
Alphafold	Q9UBR2 (Hs), Q9WUU7 (Mm), Q9R1T3 (Rn)
BRENDA	3.4.18.1
ChEMBL Target	CHEMBL4160 (Hs), CHEMBL3308941 (Rn)
Ensembl Gene	ENSG00000101160 (Hs), ENSMUSG00000016256 (Mm), ENSRNOG00000050697 (Rn)
Entrez Gene	1522 (Hs), 64138 (Mm), 252929 (Rn)
Human Protein Atlas	ENSG00000101160 (Hs)
KEGG Enzyme	3.4.18.1
KEGG Gene	hsa:1522 (Hs), mmu:64138 (Mm), rno:252929 (Rn)
OMIM	603169 (Hs)
Pharos	Q9UBR2 (Hs)
RefSeq Nucleotide	NM_001336 (Hs), NM_022325 (Mm), NM_183330 (Rn)
RefSeq Protein	NP_001327 (Hs), NP_071720 (Mm), NP_899159 (Rn)
UniProtKB	Q9UBR2 (Hs), Q9WUU7 (Mm), Q9R1T3 (Rn)
Wikipedia	CTSZ (Hs)

Enzyme Reaction
EC Number: 3.4.18.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference odanacatib Hs Inhibition 8.0 pIC50 1 ⤷ pIC50 8.0 (IC50 1x10-8 M) [1]

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Cellular signalling