dipeptidyl peptidase 8

Target id: 2356

Nomenclature: dipeptidyl peptidase 8

Family: S9: Prolyl oligopeptidase

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for dipeptidyl peptidase 8 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 898 15q22 DPP8 dipeptidyl peptidase 8
Mouse - 892 9 D Dpp8 dipeptidylpeptidase 8
Rat - - 8q24 Dpp8 dipeptidylpeptidase 8
Previous and Unofficial Names
dipeptidyl peptidase IV-related protein-1 | dipeptidyl peptidase VIII | DP8 | DPP VIII | DPRP1 | dipeptidyl-peptidase 8
Database Links
Specialist databases
MEROPS S09.018 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.14.5

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 24dd [PMID: 20684603] Hs Inhibition 6.6 pKi 2
pKi 6.6 (Ki 2.7x10-7 M) [2]
compound 18 [PMID: 15664838] Hs Inhibition 7.9 pIC50 1
pIC50 7.9 (IC50 1.4x10-8 M) [1]
1G244 Hs Inhibition 7.8 pIC50 3
pIC50 7.8 (IC50 1.4x10-8 M) [3]

References

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1. Jiaang WT, Chen YS, Hsu T, Wu SH, Chien CH, Chang CN, Chang SP, Lee SJ, Chen X. (2005) Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8. Bioorg. Med. Chem. Lett.15 (3): 687-91. [PMID:15664838]

2. Meng W, Brigance RP, Chao HJ, Fura A, Harrity T, Marcinkeviciene J, O'Connor SP, Tamura JK, Xie D, Zhang Y et al.. (2010) Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors. J. Med. Chem.53 (15): 5620-8. [PMID:20684603]

3. Wu JJ, Tang HK, Yeh TK, Chen CM, Shy HS, Chu YR, Chien CH, Tsai TY, Huang YC, Huang YL et al.. (2009) Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor. Biochem. Pharmacol.78 (2): 203-10. [PMID:19439267]

How to cite this page

S9: Prolyl oligopeptidase: dipeptidyl peptidase 8. Last modified on 30/03/2016. Accessed on 17/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2356.