coagulation factor XII

Target id: 2361

Nomenclature: coagulation factor XII

Family: S1: Chymotrypsin

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for coagulation factor XII in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 615 5q33-qter F12 coagulation factor XII
Mouse - 597 13 B2 F12 coagulation factor XII (Hageman factor)
Rat - 595 17p14 F12 coagulation factor XII
Previous and Unofficial Names
factor XII | FXII | HAF | hageman factor | coagulation factor XII (Hageman factor)
Database Links
Specialist databases
MEROPS S01.211 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.21.38

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
methyl 5-[(4-tert-butylbenzoyl)amino]-2H-1,2,4-triazole-3-carboxylate Hs Inhibition 8.0 pIC50 1
pIC50 8.0 (IC50 1.04x10-8 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Angioedema, hereditary, type III; HAE3
Synonyms: Hereditary angioedema [Disease Ontology: DOID:14735]
Hereditary angioedema type 3 [Orphanet: ORPHA100054]
Disease Ontology: DOID:14735
OMIM: 610618
Orphanet: ORPHA100054
Disease:  Factor XII deficiency
Disease Ontology: DOID:2231
OMIM: 234000
Orphanet: ORPHA330

References

Show »

1. Diamond SL. Factor XIIa 1536 HTS Dose Response Confirmation - BioAssay Summary. Accessed on 06/09/2013. Modified on 06/09/2013. PubChem, http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=852

How to cite this page

S1: Chymotrypsin: coagulation factor XII. Last modified on 29/01/2016. Accessed on 14/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2361.