coagulation factor XII | S1: Chymotrypsin | IUPHAR/BPS Guide to PHARMACOLOGY

coagulation factor XII

Target id: 2361

Nomenclature: coagulation factor XII

Family: S1: Chymotrypsin

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for coagulation factor XII in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 615 5q33-qter F12 coagulation factor XII
Mouse - 597 13 B2 F12 coagulation factor XII (Hageman factor)
Rat - 595 17p14 F12 coagulation factor XII
Previous and Unofficial Names
HAF | factor XII | FXII | hageman factor | coagulation factor XII (Hageman factor)
Database Links
Specialist databases
MEROPS S01.211 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.21.38

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
methyl 5-[(4-tert-butylbenzoyl)amino]-2H-1,2,4-triazole-3-carboxylate Hs Inhibition 8.0 pIC50 1
pIC50 8.0 (IC50 1.04x10-8 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Angioedema, hereditary, type III; HAE3
Synonyms: Hereditary angioedema [Disease Ontology: DOID:14735]
Hereditary angioedema type 3 [Orphanet: ORPHA100054]
Disease Ontology: DOID:14735
OMIM: 610618
Orphanet: ORPHA100054
Disease:  Factor XII deficiency
Disease Ontology: DOID:2231
OMIM: 234000
Orphanet: ORPHA330

References

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1. Diamond SL. Factor XIIa 1536 HTS Dose Response Confirmation - BioAssay Summary. Accessed on 06/09/2013. Modified on 06/09/2013. PubChem, http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=852

How to cite this page

S1: Chymotrypsin: coagulation factor XII. Last modified on 29/01/2016. Accessed on 25/09/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2361.