coagulation factor VII

Target id: 2363

Nomenclature: coagulation factor VII

Family: S1: Chymotrypsin

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for coagulation factor VII in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 466 13q34 F7 coagulation factor VII
Mouse - 446 8 A1.1 F7 coagulation factor VII
Rat - 446 16q12.5 F7 coagulation factor VII
Previous and Unofficial Names
factor VII | Cf7 | eptacog alfa | FVII | serum prothrombin conversion accelerator | coagulation factor VII (serum prothrombin conversion accelerator)
Database Links
Specialist databases
MEROPS S01.215 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.21.21

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 1 [PMID: 16650987] Hs Inhibition 9.0 pKi 1
pKi 9.0 (Ki 1x10-9 M) [1]
compound 11 [PMID: 16413183] Hs Inhibition ~7.0 pKi 2
pKi ~7.0 (Ki ~1x10-7 M) [2]
Description: Ki calculated from fold selectivity for KLKB1.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Factor VII deficiency
Disease Ontology: DOID:2215
OMIM: 227500
Orphanet: ORPHA327

References

Show »

1. Vijaykumar D, Rai R, Shaghafi M, Ton T, Torkelson S, Leahy EM, Riggs JR, Hu H, Sprengeler PA, Shrader WD et al.. (2006) Efforts toward oral bioavailability in factor VIIa inhibitors. Bioorg. Med. Chem. Lett.16 (14): 3829-32. [PMID:16650987]

2. Young WB, Rai R, Shrader WD, Burgess-Henry J, Hu H, Elrod KC, Sprengeler PA, Katz BA, Sukbuntherng J, Mordenti J. (2006) Small molecule inhibitors of plasma kallikrein. Bioorg. Med. Chem. Lett.16 (7): 2034-6. [PMID:16413183]

How to cite this page

S1: Chymotrypsin: coagulation factor VII. Last modified on 29/01/2016. Accessed on 18/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2363.