Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	247	14q12	GZMB	granzyme B
Mouse	-	247	14 28.19 cM	Gzmb	granzyme B
Rat	-	248	15p12	Gzmb	granzyme B

Previous and Unofficial Names

cytotoxic serine protease B | CCP1 | CCP-1/C11 | CGL1 | CSPB | CTSGL1 | fragmentin | fragmentin 2 | GLP I | GLP III | GLP-1 | granzyme B(G,H) | GZB | HLP | natural killer cell protease 1 | RNKP-1 | SECT | granzyme-like protein 1 | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

Database Links
Specialist databases
MEROPS	S01.010 (Hs)
Other databases
Alphafold	P10144 (Hs), P04187 (Mm), P18291 (Rn)
BRENDA	3.4.21.79
ChEMBL Target	CHEMBL2316 (Hs)
Ensembl Gene	ENSG00000100453 (Hs), ENSMUSG00000015437 (Mm), ENSRNOG00000049976 (Rn)
Entrez Gene	3002 (Hs), 14939 (Mm), 171528 (Rn)
Human Protein Atlas	ENSG00000100453 (Hs)
KEGG Enzyme	3.4.21.79
KEGG Gene	hsa:3002 (Hs), mmu:14939 (Mm), rno:171528 (Rn)
OMIM	123910 (Hs)
Pharos	P10144 (Hs)
RefSeq Nucleotide	NM_004131 (Hs), NM_013542 (Mm), NM_138517 (Rn)
RefSeq Protein	NP_004122 (Hs), NP_038570 (Mm), NP_612526 (Rn)
UniProtKB	P10144 (Hs), P04187 (Mm), P18291 (Rn)
Wikipedia	GZMB (Hs)

Enzyme Reaction
EC Number: 3.4.21.79

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 20 [PMID:12127536] Hs Inhibition 8.1 pKi 1 ⤷ pKi 8.1 (Ki 7x10-9 M) [1]

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  B cell (activation)

Immuno Process:  T cell (activation)