kallikrein related peptidase 2

Target id: 2372

Nomenclature: kallikrein related peptidase 2

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for kallikrein related peptidase 2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 261 19q13.33 KLK2 kallikrein related peptidase 2
Previous and Unofficial Names
Kallikrein-2 | kallikrein-related peptidase 2
Database Links
Specialist databases
MEROPS S01.161 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.21.35

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
hK2p01 derivative KLK2 inhibitor Hs Inhibition 5.8 pKi 1
pKi 5.8 (Ki 1.41x10-6 M) [1]
peptide KLK2b(c1) Hs Inhibition - - 2
[2]

References

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1. Hekim C, Leinonen J, Närvänen A, Koistinen H, Zhu L, Koivunen E, Väisänen V, Stenman UH. (2006) Novel peptide inhibitors of human kallikrein 2. J. Biol. Chem.281 (18): 12555-60. [PMID:16527822]

2. Pakkala M, Hekim C, Soininen P, Leinonen J, Koistinen H, Weisell J, Stenman UH, Vepsäläinen J, Närvänen A. (2007) Activity and stability of human kallikrein-2-specific linear and cyclic peptide inhibitors. J. Pept. Sci.13 (5): 348-53. [PMID:17436344]

How to cite this page

S1: Chymotrypsin: kallikrein related peptidase 2. Last modified on 29/01/2016. Accessed on 18/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2372.