kallikrein related peptidase 4

Target id: 2374

Nomenclature: kallikrein related peptidase 4

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for kallikrein related peptidase 4 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 254 19q13.3-q13.4 KLK4 kallikrein related peptidase 4
Mouse - 255 7 B4 Klk4 kallikrein related-peptidase 4 (prostase
Rat - 256 1q22 Klk4 kallikrein-related peptidase 4
Previous and Unofficial Names
EMSP | ESMP1 | kallikrein 4 | KLK-L1 | Prss17 | PSTS | kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)
Database Links
Specialist databases
MEROPS S01.251 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.21.-

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 33 [PMID: 19908842] Hs Inhibition 5.0 pIC50 1
pIC50 5.0 (IC50 9.772x10-6 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Amelogenesis imperfecta, hypomaturation type, IIA1; AI2A1
Synonyms: Amelogenesis imperfecta [Disease Ontology: DOID:2187]
Hypomaturation amelogenesis imperfecta [Orphanet: ORPHA100033]
Disease Ontology: DOID:2187
OMIM: 204700
Orphanet: ORPHA100033

References

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1. Mott BT, Ferreira RS, Simeonov A, Jadhav A, Ang KK, Leister W, Shen M, Silveira JT, Doyle PS, Arkin MR et al.. (2010) Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. J. Med. Chem.53 (1): 52-60. [PMID:19908842]

How to cite this page

S1: Chymotrypsin: kallikrein related peptidase 4. Last modified on 29/01/2016. Accessed on 15/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2374.