Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	1052	16q23.3-q24.1	MBTPS1	membrane bound transcription factor peptidase, site 1
Mouse	1	1052	8 E1	Mbtps1	membrane-bound transcription factor peptidase, site 1
Rat	1	1052	19q12	Mbtps1	membrane-bound transcription factor peptidase, site 1

Previous and Unofficial Names

endopeptidase S1P | PCSK8 | S1P endopeptidase | site-1 protease | Ski1 | sterol-regulated luminal protease | subtilisin/kexin isozyme 1 | membrane-bound transcription factor peptidase

Database Links
Specialist databases
MEROPS	S08.063 (Hs)
Other databases
Alphafold	Q14703 (Hs), Q9WTZ2 (Mm), Q9WTZ3 (Rn)
BRENDA	3.4.21.112
CATH/Gene3D	3.40.50.200, 3.40.50.880
ChEMBL Target	CHEMBL5916 (Hs)
Ensembl Gene	ENSG00000140943 (Hs), ENSMUSG00000031835 (Mm), ENSRNOG00000015173 (Rn)
Entrez Gene	8720 (Hs), 56453 (Mm), 89842 (Rn)
Human Protein Atlas	ENSG00000140943 (Hs)
KEGG Enzyme	3.4.21.112
KEGG Gene	hsa:8720 (Hs), mmu:56453 (Mm), rno:89842 (Rn)
OMIM	603355 (Hs)
Pharos	Q14703 (Hs)
RefSeq Nucleotide	NM_003791 (Hs), NM_001167910 (Mm), NM_019709 (Mm), NM_053569 (Rn)
RefSeq Protein	NP_003782 (Hs), NP_062683 (Mm), NP_001161382 (Mm), NP_446021 (Rn)
UniProtKB	Q14703 (Hs), Q9WTZ2 (Mm), Q9WTZ3 (Rn)
Wikipedia	MBTPS1 (Hs)

Enzyme Reaction
EC Number: 3.4.21.112

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 7b [PMID: 17583500] Hs Inhibition 8.1 pIC50 2 ⤷ pIC50 8.1 (IC50 8x10-9 M) [2]

General Comments
MBTPS1 is an important posttranscriptional modulator of sterol regulatory element-binding proteins (SREBPs), which are proteins that transcriptionally regulate cholesterol, fatty acid, and glucose metabolism. Pharmacologic inhibition of MBTPS1 reduces lipogenic enzyme gene expression and lipid synthesis in vitro and in vivo [1].