proprotein convertase subtilisin/kexin type 5

Target id: 2385

Nomenclature: proprotein convertase subtilisin/kexin type 5

Family: S8: Subtilisin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for proprotein convertase subtilisin/kexin type 5 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1860 9 PCSK5 proprotein convertase subtilisin/kexin type 5
Mouse - 1877 19 B Pcsk5 proprotein convertase subtilisin/kexin type 5
Rat - 915 1q43 Pcsk5 proprotein convertase subtilisin/kexin type 5
Previous and Unofficial Names
PC5/6A | PC5A | PC6 | proprotein convertase 5 | proprotein convertase 6 | SPC6
Database Links
Specialist databases
MEROPS S08.076 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.21.-

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
phenylacetyl-Arg-Val-Arg-4-amidinobenzylamide Hs Inhibition 8.8 pKi 1
pKi 8.8 (Ki 1.6x10-9 M) [1]
furin inhibitor peptide Hs Inhibition 6.6 pKi 2
pKi 6.6 (Ki 2.32x10-7 M) [2]

References

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1. Becker GL, Sielaff F, Than ME, Lindberg I, Routhier S, Day R, Lu Y, Garten W, Steinmetzer T. (2010) Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics. J. Med. Chem.53 (3): 1067-75. [PMID:20038105]

2. Shiryaev SA, Remacle AG, Ratnikov BI, Nelson NA, Savinov AY, Wei G, Bottini M, Rega MF, Parent A, Desjardins R et al.. (2007) Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens. J. Biol. Chem.282 (29): 20847-53. [PMID:17537721]

How to cite this page

S8: Subtilisin: proprotein convertase subtilisin/kexin type 5. Last modified on 28/07/2015. Accessed on 23/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2385.