proprotein convertase subtilisin/kexin type 5

Target id: 2385

Nomenclature: proprotein convertase subtilisin/kexin type 5

Family: S8: Subtilisin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for proprotein convertase subtilisin/kexin type 5 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1860 9 PCSK5 proprotein convertase subtilisin/kexin type 5
Mouse - 1877 19 B Pcsk5 proprotein convertase subtilisin/kexin type 5
Rat - 915 1q43 Pcsk5 proprotein convertase subtilisin/kexin type 5
Previous and Unofficial Names
PC5/6A | PC5A | PC6 | proprotein convertase 5 | proprotein convertase 6 | SPC6
Database Links
Specialist databases
MEROPS S08.076 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: 3.4.21.-

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
phenylacetyl-Arg-Val-Arg-4-amidinobenzylamide Hs Inhibition 8.8 pKi 1
pKi 8.8 (Ki 1.6x10-9 M) [1]
furin inhibitor peptide Hs Inhibition 6.6 pKi 2
pKi 6.6 (Ki 2.32x10-7 M) [2]


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1. Becker GL, Sielaff F, Than ME, Lindberg I, Routhier S, Day R, Lu Y, Garten W, Steinmetzer T. (2010) Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics. J. Med. Chem.53 (3): 1067-75. [PMID:20038105]

2. Shiryaev SA, Remacle AG, Ratnikov BI, Nelson NA, Savinov AY, Wei G, Bottini M, Rega MF, Parent A, Desjardins R et al.. (2007) Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens. J. Biol. Chem.282 (29): 20847-53. [PMID:17537721]

How to cite this page

S8: Subtilisin: proprotein convertase subtilisin/kexin type 5. Last modified on 28/07/2015. Accessed on 24/04/2018. IUPHAR/BPS Guide to PHARMACOLOGY,