proprotein convertase subtilisin/kexin type 7

Target id: 2387

Nomenclature: proprotein convertase subtilisin/kexin type 7

Family: S8: Subtilisin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for proprotein convertase subtilisin/kexin type 7 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 785 11q23-q24 PCSK7 proprotein convertase subtilisin/kexin type 7
Mouse - 770 9 A5.2 Pcsk7 proprotein convertase subtilisin/kexin type 7
Rat - 783 8q22 Pcsk7 proprotein convertase subtilisin/kexin type 7
Previous and Unofficial Names
LPC | PC8 | prohormone convertase 7 | prohormone convertase PC7 | SPC7
Database Links
Specialist databases
MEROPS S08.077 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.21.-

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
peptide 18 [PMID: 24350995] Hs Inhibition 7.9 pKi 1
pKi 7.9 (Ki 1.38x10-8 M) [1]
furin inhibitor peptide Hs Inhibition 6.8 pKi 2
pKi 6.8 (Ki 1.52x10-7 M) [2]

References

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1. Kwiatkowska A, Couture F, Levesque C, Ly K, Desjardins R, Beauchemin S, Prahl A, Lammek B, Neugebauer W, Dory YL et al.. (2014) Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor. J. Med. Chem.57 (1): 98-109. [PMID:24350995]

2. Shiryaev SA, Remacle AG, Ratnikov BI, Nelson NA, Savinov AY, Wei G, Bottini M, Rega MF, Parent A, Desjardins R et al.. (2007) Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens. J. Biol. Chem.282 (29): 20847-53. [PMID:17537721]

How to cite this page

S8: Subtilisin: proprotein convertase subtilisin/kexin type 7. Last modified on 28/07/2015. Accessed on 13/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2387.