Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	493	19q13.11	PEPD	peptidase D
Mouse	-	493	7 20.7 cM	Pepd	peptidase D
Rat	-	492	1q21	Pepd	peptidase D

Previous and Unofficial Names

imidodipeptidase | Pep4 | peptidase 4 | prolidase | proline dipeptidase

Database Links
Specialist databases
MEROPS	M24.007 (Hs)
Other databases
Alphafold	P12955 (Hs), Q11136 (Mm), Q5I0D7 (Rn)
BRENDA	3.4.13.9
CATH/Gene3D	3.40.350.10
ChEMBL Target	CHEMBL4185 (Hs)
Ensembl Gene	ENSG00000124299 (Hs), ENSMUSG00000063931 (Mm), ENSRNOG00000052945 (Rn)
Entrez Gene	5184 (Hs), 18624 (Mm), 292808 (Rn)
Human Protein Atlas	ENSG00000124299 (Hs)
KEGG Enzyme	3.4.13.9
KEGG Gene	hsa:5184 (Hs), mmu:18624 (Mm), rno:292808 (Rn)
OMIM	613230 (Hs)
Orphanet	ORPHA124187 (Hs)
Pharos	P12955 (Hs)
RefSeq Nucleotide	NM_000285 (Hs), NM_001166057 (Hs), NM_001166056 (Hs), NM_008820 (Mm), NM_001009641 (Rn)
RefSeq Protein	NP_001159529 (Hs), NP_001159528 (Hs), NP_000276 (Hs), NP_032846 (Mm), NP_001009641 (Rn)
UniProtKB	P12955 (Hs), Q11136 (Mm), Q5I0D7 (Rn)
Wikipedia	PEPD (Hs)

Enzyme Reaction
EC Number: 3.4.13.9

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference phosphoenolpyruvic acid Pig Inhibition 9.5 – 9.6 pKi 1 ⤷ pKi 9.5 – 9.6 (Ki 3x10-10 – 2.4x10-10 M) [1] Description: Biphasic inhibition of purified enzyme from pig kidney.

Clinically-Relevant Mutations and Pathophysiology
Disease:  Prolidase deficiency OMIM: 170100 Orphanet: ORPHA742