SMO

Target id: 239

Nomenclature: SMO

Family: Class Frizzled GPCRs

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for SMO in GtoImmuPdb

Gene and Protein Information
Frizzled family G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 787 7q32.3 SMO smoothened, frizzled class receptor
Mouse 7 793 6 A3.3 Smo smoothened
Rat 7 793 4q22 Smo smoothened
Previous and Unofficial Names
SMOH | FZD11 | frizzled family member 11 | bnb | smoothened, frizzled class receptor | smoothened
Database Links
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Structure of the human smoothened 7TM receptor in complex with an antitumor agent
PDB Id:  4JKV
Resolution:  2.45Å
Species:  Human
References:  14
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand, TC114
PDB Id:  5V56
Ligand:  TC114
Resolution:  2.9Å
Species:  None
References:  17
Natural/Endogenous Ligands
constitutive

Download all structure-activity data for this target as a CSV file

Agonist Comments
Oxysterols might be endogenous agonists of the SMO receptor [2].
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
sonidegib Hs Antagonist 8.2 pKi 15
pKi 8.2 (Ki 6x10-9 M) [15]
vismodegib Hs Antagonist 7.8 pKi 15
pKi 7.8 (Ki 1.62x10-8 M) [15]
saridegib Hs Antagonist 8.9 pIC50 13
pIC50 8.9 (IC50 1.4x10-9 M) [13]
AZD8542 Mm Antagonist 8.8 pIC50 1
pIC50 8.8 (IC50 1.5x10-9 M) [1]
AZD8542 Hs Antagonist 8.5 pIC50 1
pIC50 8.5 (IC50 3x10-9 M) [1]
TAK-441 Mm Antagonist 8.4 pIC50 8
pIC50 8.4 (IC50 4.4x10-9 M) [8]
glasdegib Hs Antagonist 8.3 pIC50 7
pIC50 8.3 (IC50 5x10-9 M) [7]
View species-specific antagonist tables
Antagonist Comments
In addition to the approved drug vismodegib, there are several more Hedgehog inhibitors (Hhi) in the drug development pipeline. Most of these compounds inhibit the hedgehog signaling pathway via antagonism of Smoothened (SMO), a key component of the pathway and include saridegib, erismodegib, BMS-833923 (XL139), TAK-441 and glasdegib (PF-04449913).
Primary Transduction Mechanisms
Transducer Effector/Response
Gi/Go family
G12/G13 family
References:  3,9
Secondary Transduction Mechanisms
Transducer Effector/Response
Phospholipase A2 stimulation
References: 
Tissue Distribution
The SMO receptor is widely expressed.
Species:  Mouse
Technique:  Northern blotting.
References:  10
The SMO receptor is widely expressed.
Species:  Rat
Technique:  Northern blotting.
References:  10
Brain.
Species:  Rat
Technique:  Northern blotting.
References:  12
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays
Hedgehog reporter assay in HEK 293 cells transfected with the SMO receptor and Gα12.
Species:  Human
Tissue:  HEK 293 cells.
Response measured:  Hedgehog reporter assay and Gli3 localisation.
References:  3
Measurement of IP3 levels in HEK 293 cells transfected with the SMO receptor and G15.
Species:  Human
Tissue:  HEK 293 cells.
Response measured:  Stimulation of IP5 production.
References:  5
Measurement of GTPγS binding in Sf9 cells transfected with the mouse SMO receptor and G proteins.
Species:  Mouse
Tissue:  Sf9 insect cells.
Response measured:  Stimulation of GTPγS binding.
References:  9
Determination of the role of GRK2 in SMO receptor functioning.
Species:  Mouse
Tissue:  C3H10T1/2 mouse cells.
Response measured:  Hedgehog/Gli reporter assay.
References:  6
Physiological Functions
SMO functions in Hedgehog signal transduction (gene targeting).
Species:  Mouse
Tissue:  Widespread.
References:  18
Physiological Consequences of Altering Gene Expression
Increasing SMO receptor expression activates Hedgehog signalling in a ligand-independent manner.
Species:  Mouse
Tissue: 
Technique:  Transgenesis.
References:  11
SMO receptor knockout is embryonically lethal.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  18
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Smotm1Amc|Smotm2Amc|Tg(KRT14-cre)1Amc Smotm1Amc/Smotm2Amc,Tg(KRT14-cre)1Amc/0
involves: 129X1/SvJ * C57BL/6 * CBA
MGI:108075  MGI:2450263  MP:0002650 abnormal ameloblast morphology PMID: 12403705 
Isl1+|Isl1tm1(cre)Sev|Smotm1Amc|Smotm2Amc Isl1tm1(cre)Sev/Isl1+,Smotm1Amc/Smotm2Amc
involves: 129X1/SvJ
MGI:101791  MGI:108075  MP:0004113 abnormal aortic arch morphology PMID: 16687132 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0000106 abnormal basisphenoid bone morphology PMID: 15107405 
En1tm2(cre)Wrst|Gli3tm1Alj|Smotm2Amc En1tm2(cre)Wrst/?,Gli3tm1Alj/Gli3tm1Alj,Smotm2Amc/Smotm2Amc
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MGI:108075  MGI:95389  MGI:95729  MP:0000822 abnormal brain ventricle morphology PMID: 18480159 
Smotm1Amc|Smotm2Amc|Tg(Nes-cre)1Kln Smotm1Amc/Smotm2Amc,Tg(Nes-cre)1Kln/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL * Swiss Webster
MGI:108075  MGI:2176172  MP:0000857 abnormal cerebellar foliation PMID: 16571625 
En1tm2(cre)Wrst|Gli3tm1Alj|Smotm2Amc En1tm2(cre)Wrst/?,Gli3tm1Alj/Gli3tm1Alj,Smotm2Amc/Smotm2Amc
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MGI:108075  MGI:95389  MGI:95729  MP:0000857 abnormal cerebellar foliation PMID: 18480159 
Smotm1Amc|Smotm2Amc|Tg(Nes-cre)1Kln Smotm1Amc/Smotm2Amc,Tg(Nes-cre)1Kln/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL * Swiss Webster
MGI:108075  MGI:2176172  MP:0000849 abnormal cerebellum morphology PMID: 16571625 
En1tm2(cre)Wrst|Gli3tm1Alj|Smotm2Amc En1tm2(cre)Wrst/?,Gli3tm1Alj/Gli3tm1Alj,Smotm2Amc/Smotm2Amc
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MGI:108075  MGI:95389  MGI:95729  MP:0000849 abnormal cerebellum morphology PMID: 18480159 
Smotm1Amc|Smotm2Amc|Tg(Col2a1-cre)10Amc Smotm1Amc/Smotm2Amc,Tg(Col2a1-cre)10Amc/0
involves: 129X1/SvJ
MGI:108075  MGI:2176261  MP:0000166 abnormal chondrocyte morphology PMID: 11748145 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0003935 abnormal craniofacial development PMID: 15107405 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0000438 abnormal cranium morphology PMID: 15107405 
Smotm1.1Pab Smotm1.1Pab/Smotm1.1Pab
Not Specified
MGI:108075  MP:0002084 abnormal developmental patterning PMID: 12372301 
Smotm1Amc|Smotm2Amc|Tg(Fgf15-cre)1Hisa Smotm1Amc/Smotm2Amc,Tg(Fgf15-cre)1Hisa/0
involves: 129X1/SvJ * Swiss Webster
MGI:108075  MGI:4430280  MP:0000830 abnormal diencephalon morphology PMID: 19854269 
Smotm1Amc|Smotm2Amc|Tg(Col2a1-cre)10Amc Smotm1Amc/Smotm2Amc,Tg(Col2a1-cre)10Amc/0
involves: 129X1/SvJ
MGI:108075  MGI:2176261  MP:0002110 abnormal digit morphology PMID: 11748145 
Smobnb Smobnb/Smobnb
involves: C3H/HeJ * C57BL/6J
MGI:108075  MP:0004190 abnormal direction of embryo turning PMID: 9636176 
Ift172wim|Smobnb Ift172wim/Ift172wim,Smobnb/Smobnb
involves: C57BL/6J
MGI:108075  MGI:2682064  MP:0004252 abnormal direction of looping morphogenesis PMID: 16061793 
Smotm1Amc Smotm1Amc/Smotm1Amc
involves: 129X1/SvJ * C57BL/6
MGI:108075  MP:0001672 abnormal embryogenesis/ development PMID: 17881493 
Smotm1.1Pab Smotm1.1Pab/Smotm1.1Pab
Not Specified
MGI:108075  MP:0001700 abnormal embryo turning PMID: 12372301 
Smotm1Amc Smotm1Amc/Smotm1Amc
involves: 129X1/SvJ * C57BL/6
MGI:108075  MP:0001700 abnormal embryo turning PMID: 17881493 
Smotm1Amc|Smotm2Amc|Tg(KRT14-cre)1Amc Smotm1Amc/Smotm2Amc,Tg(KRT14-cre)1Amc/0
involves: 129X1/SvJ * C57BL/6 * CBA
MGI:108075  MGI:2450263  MP:0002576 abnormal enamel morphology PMID: 12403705 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0000100 abnormal ethmoidal bone morphology PMID: 15107405 
Smotm1.1Pab Smotm1.1Pab/Smotm1.1Pab
Not Specified
MGI:108075  MP:0006337 abnormal first branchial arch morphology PMID: 12372301 
Smotm1Amc|Tctn1Gt(KST296)Byg Tctn1Gt(KST296)Byg/Tctn1Gt(KST296)Byg,Smotm1Amc/Smotm1Amc
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
MGI:108075  MGI:3603820  MP:0000783 abnormal forebrain morphology PMID: 16357211 
En1tm2(cre)Wrst|Gli3tm1Alj|Smotm2Amc En1tm2(cre)Wrst/?,Gli3tm1Alj/Gli3tm1Alj,Smotm2Amc/Smotm2Amc
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MGI:108075  MGI:95389  MGI:95729  MP:0000841 abnormal hindbrain morphology PMID: 18480159 
Smotm1Amc|Smotm2Amc|Tg(KRT14-cre)1Amc Smotm1Amc/Smotm2Amc,Tg(KRT14-cre)1Amc/0
involves: 129X1/SvJ * C57BL/6 * CBA
MGI:108075  MGI:2450263  MP:0005358 abnormal incisor morphology PMID: 12403705 
Gt(ROSA)26Sortm6Dym|Smotm2Amc|Sox9+|Sox9tm3(cre)Crm Gt(ROSA)26Sortm6Dym/?,Smotm2Amc/Smotm2Amc,Sox9tm3(cre)Crm/Sox9+
involves: 129S7/SvEvBrd * 129X1/SvJ
MGI:104735  MGI:108075  MGI:98371  MP:0002932 abnormal joint morphology PMID: 19815519 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0005271 abnormal lacrimal bone morphology PMID: 15107405 
Smobnb Smobnb/Smobnb
involves: C3HeB/FeJ * C57BL/6J
MGI:108075  MP:0001706 abnormal left-right axis patterning PMID: 15755804 
Smotm1Amc|Smotm2Amc|Tg(Fgf15-cre)1Hisa Smotm1Amc/Smotm2Amc,Tg(Fgf15-cre)1Hisa/0
involves: 129X1/SvJ * Swiss Webster
MGI:108075  MGI:4430280  MP:0005545 abnormal lens development PMID: 19854269 
Smobnb Smobnb/Smobnb
involves: C3H/HeJ * C57BL/6J
MGI:108075  MP:0000269 abnormal looping morphogenesis PMID: 9636176 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0000458 abnormal mandible morphology PMID: 15107405 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0004595 abnormal mandibular condyloid process morphology PMID: 15107405 
Gt(ROSA)26Sortm6Dym|Smotm2Amc|Sox9+|Sox9tm3(cre)Crm Gt(ROSA)26Sortm6Dym/?,Smotm2Amc/Smotm2Amc,Sox9tm3(cre)Crm/Sox9+
involves: 129S7/SvEvBrd * 129X1/SvJ
MGI:104735  MGI:108075  MGI:98371  MP:0004595 abnormal mandibular condyloid process morphology PMID: 19815519 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0000455 abnormal maxilla morphology PMID: 15107405 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0005587 abnormal Meckel's cartilage morphology PMID: 15107405 
Smotm1Amc|Smotm2Amc|Tg(KRT14-cre)1Amc Smotm1Amc/Smotm2Amc,Tg(KRT14-cre)1Amc/0
involves: 129X1/SvJ * C57BL/6 * CBA
MGI:108075  MGI:2450263  MP:0003932 abnormal molar crown morphology PMID: 12403705 
Smotm1Amc|Smotm2Amc|Tg(KRT14-cre)1Amc Smotm1Amc/Smotm2Amc,Tg(KRT14-cre)1Amc/0
involves: 129X1/SvJ * C57BL/6 * CBA
MGI:108075  MGI:2450263  MP:0002689 abnormal molar morphology PMID: 12403705 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0002239 abnormal nasal septum morphology PMID: 15107405 
Isl1+|Isl1tm1(cre)Sev|Smotm1Amc|Smotm2Amc Isl1tm1(cre)Sev/Isl1+,Smotm1Amc/Smotm2Amc
involves: 129X1/SvJ
MGI:101791  MGI:108075  MP:0002950 abnormal neural crest cell migration PMID: 16687132 
Smotm1.1Pab Smotm1.1Pab/Smotm1.1Pab
Not Specified
MGI:108075  MP:0004837 abnormal neural fold formation PMID: 12372301 
Smotm1.1Pab Smotm1.1Pab/Smotm1.1Pab
Not Specified
MGI:108075  MP:0005657 abnormal neural plate morphology PMID: 12372301 
Smotm1Amc|Tulp3hhkr Smotm1Amc/Smotm1Amc,Tulp3hhkr/Tulp3hhkr
involves: 129X1/SvJ * C3H/HeH * C57BL/6
MGI:108075  MGI:1329045  MP:0002151 abnormal neural tube morphology/development PMID: 19223390 
Kif7tm1.2Hui|Smotm1Amc Kif7tm1.2Hui/Kif7tm1.2Hui,Smotm1Amc/Smotm1Amc
involves: 129S6/SvEvTac * 129X1/SvJ * CD-1
MGI:108075  MGI:1098239  MP:0002151 abnormal neural tube morphology/development PMID: 19549984 
Kif7tm1.2Hui|Smotm1Amc Kif7tm1.2Hui/Kif7tm1.2Hui,Smotm1Amc/Smotm1Amc
involves: 129S6/SvEvTac * 129X1/SvJ * CD-1
MGI:108075  MGI:1098239  MP:0009937 abnormal neuron differentiation PMID: 19549984 
Smotm1Amc|Smotm2Amc|Tg(Fgf15-cre)1Hisa Smotm1Amc/Smotm2Amc,Tg(Fgf15-cre)1Hisa/0
involves: 129X1/SvJ * Swiss Webster
MGI:108075  MGI:4430280  MP:0004269 abnormal optic cup morphology PMID: 19854269 
Smotm1Amc|Smotm2Amc|Tg(Fgf15-cre)1Hisa Smotm1Amc/Smotm2Amc,Tg(Fgf15-cre)1Hisa/0
involves: 129X1/SvJ * Swiss Webster
MGI:108075  MGI:4430280  MP:0004268 abnormal optic stalk morphology PMID: 19854269 
Smotm1.1Pab Smotm1.1Pab/Smotm1.1Pab
Not Specified
MGI:108075  MP:0003425 abnormal optic vesicle formation PMID: 12372301 
Smotm1Amc|Smotm2Amc|Tg(Fgf15-cre)1Hisa Smotm1Amc/Smotm2Amc,Tg(Fgf15-cre)1Hisa/0
involves: 129X1/SvJ * Swiss Webster
MGI:108075  MGI:4430280  MP:0003425 abnormal optic vesicle formation PMID: 19854269 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0004457 abnormal orbitosphenoid bone morphology PMID: 15107405 
Smotm1Amc|Smotm2Amc|Tg(Fgf15-cre)1Hisa Smotm1Amc/Smotm2Amc,Tg(Fgf15-cre)1Hisa/0
involves: 129X1/SvJ * Swiss Webster
MGI:108075  MGI:4430280  MP:0006030 abnormal otic vesicle development PMID: 19854269 
Isl1+|Isl1tm1(cre)Sev|Smotm1Amc|Smotm2Amc Isl1tm1(cre)Sev/Isl1+,Smotm1Amc/Smotm2Amc
involves: 129X1/SvJ
MGI:101791  MGI:108075  MP:0006126 abnormal outflow tract development PMID: 16687132 
En1tm2(cre)Wrst|Gli3tm1Alj|Smotm2Amc En1tm2(cre)Wrst/?,Gli3tm1Alj/Gli3tm1Alj,Smotm2Amc/Smotm2Amc
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MGI:108075  MGI:95389  MGI:95729  MP:0000933 abnormal rhombomere morphology PMID: 18480159 
Isl1+|Isl1tm1(cre)Sev|Smotm1Amc|Smotm2Amc Isl1tm1(cre)Sev/Isl1+,Smotm1Amc/Smotm2Amc
involves: 129X1/SvJ
MGI:101791  MGI:108075  MP:0006355 abnormal sixth branchial arch artery morphology PMID: 16687132 
Smotm1Amc|Smotm2Amc|Tg(Col2a1-cre)10Amc Smotm1Amc/Smotm2Amc,Tg(Col2a1-cre)10Amc/0
involves: 129X1/SvJ
MGI:108075  MGI:2176261  MP:0002113 abnormal skeleton development PMID: 11748145 
Smotm1Amc|Smotm2Amc|Tg(Col2a1-cre)10Amc Smotm1Amc/Smotm2Amc,Tg(Col2a1-cre)10Amc/0
involves: 129X1/SvJ
MGI:108075  MGI:2176261  MP:0002115 abnormal skeleton extremities morphology PMID: 11748145 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0000104 abnormal sphenoid bone morphology PMID: 15107405 
Smobnb Smobnb/Smobnb
involves: C3HeB/FeJ * C57BL/6J
MGI:108075  MP:0000955 abnormal spinal cord morphology PMID: 15755804 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0004423 abnormal squamosal bone morphology PMID: 15107405 
En1tm2(cre)Wrst|Gli3tm1Alj|Smotm2Amc En1tm2(cre)Wrst/?,Gli3tm1Alj/Gli3tm1Alj,Smotm2Amc/Smotm2Amc
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MGI:108075  MGI:95389  MGI:95729  MP:0006104 abnormal tectum morphology PMID: 18480159 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0005272 abnormal temporal bone morphology PMID: 15107405 
Olig3+|Olig3tm1(cre)Ynka|Smotm2Amc Olig3tm1(cre)Ynka/Olig3+,Smotm2Amc/Smotm2Amc
involves: 129X1/SvJ * C57BL/6J
MGI:108075  MGI:2149955  MP:0000832 abnormal thalamus morphology PMID: 19357274 
Smotm2Amc|Tg(Nes-cre)1Kln Smotm2Amc/Smotm2Amc,Tg(Nes-cre)1Kln/0
involves: 129X1/SvJ * C57BL/6 * SJL
MGI:108075  MGI:2176172  MP:0000832 abnormal thalamus morphology PMID: 19357274 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0002260 abnormal thyroid cartilage morphology PMID: 15107405 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0002100 abnormal tooth morphology PMID: 15107405 
Smotm1Amc Smotm1Amc/Smotm1Amc
involves: 129X1/SvJ * C57BL/6
MGI:108075  MP:0003229 abnormal vitelline vasculature morphology PMID: 17881493 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0008381 absent gonial bone PMID: 15107405 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0004318 absent incus PMID: 15107405 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0004791 absent lower incisors PMID: 15107405 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0004319 absent malleus PMID: 15107405 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0000040 absent middle ear ossicles PMID: 15107405 
Kif7tm1.2Hui|Smotm1Amc Kif7tm1.2Hui/Kif7tm1.2Hui,Smotm1Amc/Smotm1Amc
involves: 129S6/SvEvTac * 129X1/SvJ * CD-1
MGI:108075  MGI:1098239  MP:0004949 absent neuronal precursor cells PMID: 19549984 
Smotm1Amc Smotm1Amc/Smotm1Amc
involves: 129X1/SvJ * CD-1
MGI:108075  MP:0004949 absent neuronal precursor cells PMID: 19549984 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0004476 absent palatine bone PMID: 15107405 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0004449 absent presphenoid bone PMID: 15107405 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0004454 absent pterygoid process PMID: 15107405 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0004916 absent Reichert cartilage PMID: 15107405 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0004204 absent stapes PMID: 15107405 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0008386 absent styloid process PMID: 15107405 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0009905 absent tongue PMID: 15107405 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0003138 absent tympanic ring PMID: 15107405 
Bmp4+|Bmp4tm2Blh|Smotm1Amc Bmp4tm2Blh/Bmp4+,Smotm1Amc/Smotm1Amc
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MGI:108075  MGI:88180  MP:0001719 absent vitelline blood vessels PMID: 17881493 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0000099 absent vomer bone PMID: 15107405 
Smotm1Amc|Smotm2Amc|Tg(Fgf15-cre)1Hisa Smotm1Amc/Smotm2Amc,Tg(Fgf15-cre)1Hisa/0
involves: 129X1/SvJ * Swiss Webster
MGI:108075  MGI:4430280  MP:0001293 anophthalmia PMID: 19854269 
Smotm2Amc|Tg(Gfap-cre)73.12Mvs Smotm2Amc/Smotm2Amc,Tg(Gfap-cre)73.12Mvs/0
involves: 129X1/SvJ * BALB/c * C57BL/6NHsd
MGI:108075  MGI:3522207  MP:0003354 astrocytosis PMID: 20943901 
Isl1+|Isl1tm1(cre)Sev|Smotm1Amc|Smotm2Amc Isl1tm1(cre)Sev/Isl1+,Smotm1Amc/Smotm2Amc
involves: 129X1/SvJ
MGI:101791  MGI:108075  MP:0010403 atrial septal defect PMID: 16687132 
Smobnb Smobnb/Smobnb
involves: C3H/HeJ * C57BL/6J
MGI:108075  MP:0004574 broad limb buds PMID: 9636176 
Smotm1Amc|Smotm2Amc|Tg(Nes-cre)1Kln Smotm1Amc/Smotm2Amc,Tg(Nes-cre)1Kln/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL * Swiss Webster
MGI:108075  MGI:2176172  MP:0000774 decreased brain size PMID: 16571625 
Smotm1.1Pab Smotm1.1Pab/Smotm1.1Pab
Not Specified
MGI:108075  MP:0001698 decreased embryo size PMID: 12372301 
Smobnb Smobnb/Smobnb
involves: C3H/HeJ * C57BL/6J
MGI:108075  MP:0001698 decreased embryo size PMID: 9636176 
Smotm1Amc|Smotm2Amc|Tg(Fgf15-cre)1Hisa Smotm1Amc/Smotm2Amc,Tg(Fgf15-cre)1Hisa/0
involves: 129X1/SvJ * Swiss Webster
MGI:108075  MGI:4430280  MP:0001698 decreased embryo size PMID: 19854269 
Smotm1Amc|Smotm2Amc|Tg(Col2a1-cre)10Amc Smotm1Amc/Smotm2Amc,Tg(Col2a1-cre)10Amc/0
involves: 129X1/SvJ
MGI:108075  MGI:2176261  MP:0004686 decreased length of long bones PMID: 11748145 
Smotm1Amc|Smotm2Amc|Tg(Col2a1-cre)15Amc Smotm1Amc/Smotm2Amc,Tg(Col2a1-cre)15Amc/0
involves: 129X1/SvJ
MGI:108075  MGI:2176259  MP:0004686 decreased length of long bones PMID: 11748145 
Smotm1Amc|Smotm2Amc|Tg(Col2a1-cre)3Amc Smotm1Amc/Smotm2Amc,Tg(Col2a1-cre)3Amc/0
involves: 129X1/SvJ
MGI:108075  MGI:2176260  MP:0004686 decreased length of long bones PMID: 11748145 
Ift172wim|Smobnb Ift172wim/Ift172wim,Smobnb/Smobnb
involves: C57BL/6J
MGI:108075  MGI:2682064  MP:0000939 decreased motor neuron number PMID: 16061793 
Smotm1.1Pab Smotm1.1Pab/Smotm1.1Pab
Not Specified
MGI:108075  MP:0000292 distended pericardium PMID: 12372301 
Smotm1Amc Smotm1Amc/Smotm1Amc
involves: 129X1/SvJ * CD-1
MGI:108075  MP:0003984 embryonic growth retardation PMID: 19549984 
Smobnb Smobnb/Smobnb
involves: C3HeB/FeJ * C57BL/6J
MGI:108075  MP:0006207 embryonic lethality during organogenesis PMID: 15755804 
Ift172wim|Smobnb Ift172wim/Ift172wim,Smobnb/Smobnb
involves: C57BL/6J
MGI:108075  MGI:2682064  MP:0006207 embryonic lethality during organogenesis PMID: 16061793 
Kif7maki|Smobnb|Tg(Hlxb9-GFP)1Tmj Kif7maki/Kif7maki,Smobnb/Smobnb,Tg(Hlxb9-GFP)1Tmj/?
involves: C57BL/6J * FVB/N
MGI:108075  MGI:1098239  MGI:3037037  MP:0006207 embryonic lethality during organogenesis PMID: 19666503 
En1tm2(cre)Wrst|Gli3tm1Alj|Smotm2Amc En1tm2(cre)Wrst/?,Gli3tm1Alj/Gli3tm1Alj,Smotm2Amc/Smotm2Amc
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MGI:108075  MGI:95389  MGI:95729  MP:0009048 enlarged tectum PMID: 18480159 
Kif7tm1.2Hui|Smotm1Amc Kif7tm1.2Hui/Kif7tm1.2Hui,Smotm1Amc/Smotm1Amc
involves: 129S6/SvEvTac * 129X1/SvJ * CD-1
MGI:108075  MGI:1098239  MP:0000914 exencephaly PMID: 19549984 
Smotm1Amc|Smotm2Amc|Tg(Fgf15-cre)1Hisa Smotm1Amc/Smotm2Amc,Tg(Fgf15-cre)1Hisa/0
involves: 129X1/SvJ * Swiss Webster
MGI:108075  MGI:4430280  MP:0000784 forebrain hypoplasia PMID: 19854269 
Smotm1.1Pab Smotm1.1Pab/Smotm1.1Pab
Not Specified
MGI:108075  MP:0010335 fused first branchial arch PMID: 12372301 
Smobnb Smobnb/Smobnb
involves: C3H/HeJ * C57BL/6J
MGI:108075  MP:0001914 hemorrhage PMID: 9636176 
Smobnb Smobnb/Smobnb
involves: C3H/HeJ * C57BL/6J
MGI:108075  MP:0001701 incomplete embryo turning PMID: 9636176 
Smotm1Amc|Tulp3hhkr Smotm1Amc/Smotm1Amc,Tulp3hhkr/Tulp3hhkr
involves: 129X1/SvJ * C3H/HeH * C57BL/6
MGI:108075  MGI:1329045  MP:0002809 increased spinal cord size PMID: 19223390 
Smotm1Amc|Smotm2Amc|Tg(KRT14-cre)1Amc Smotm1Amc/Smotm2Amc,Tg(KRT14-cre)1Amc/0
involves: 129X1/SvJ * C57BL/6 * CBA
MGI:108075  MGI:2450263  MP:0002058 neonatal lethality PMID: 12403705 
Smotm2Amc|Tg(mI56i-cre,EGFP)1Kc Smotm2Amc/Smotm2Amc,Tg(mI56i-cre,EGFP)1Kc/?
involves: 129X1/SvJ
MGI:108075  MGI:3609984  MP:0002169 no abnormal phenotype detected PMID: 16221724 
Smotm1Amc|Smotm2Amc|Tg(Sp7-tTA,tetO-EGFP/cre)1Amc Smotm1Amc/Smotm2Amc,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
involves: 129X1/SvJ * CD-1
MGI:108075  MGI:3689349  MP:0002169 no abnormal phenotype detected PMID: 16854976 
Ift172wim|Smobnb Ift172wim/Ift172wim,Smobnb/Smobnb
involves: C57BL/6J
MGI:108075  MGI:2682064  MP:0000929 open neural tube PMID: 16061793 
Smobnb Smobnb/Smobnb
involves: C3H/HeJ * C57BL/6J
MGI:108075  MP:0001787 pericardial edema PMID: 9636176 
Smotm1Amc|Tulp3hhkr Smotm1Amc/Smotm1Amc,Tulp3hhkr/Tulp3hhkr
involves: 129X1/SvJ * C3H/HeH * C57BL/6
MGI:108075  MGI:1329045  MP:0001787 pericardial edema PMID: 19223390 
Isl1+|Isl1tm1(cre)Sev|Smotm1Amc|Smotm2Amc Isl1tm1(cre)Sev/Isl1+,Smotm1Amc/Smotm2Amc
involves: 129X1/SvJ
MGI:101791  MGI:108075  MP:0002081 perinatal lethality PMID: 16687132 
Isl1+|Isl1tm1(cre)Sev|Smotm1Amc|Smotm2Amc Isl1tm1(cre)Sev/Isl1+,Smotm1Amc/Smotm2Amc
involves: 129X1/SvJ
MGI:101791  MGI:108075  MP:0002633 persistent truncus arteriosis PMID: 16687132 
Smotm1Amc|Smotm2Amc|Tg(Col2a1-cre)10Amc Smotm1Amc/Smotm2Amc,Tg(Col2a1-cre)10Amc/0
involves: 129X1/SvJ
MGI:108075  MGI:2176261  MP:0002082 postnatal lethality PMID: 11748145 
Smotm1Amc|Smotm2Amc|Tg(Nes-cre)1Kln Smotm1Amc/Smotm2Amc,Tg(Nes-cre)1Kln/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL * Swiss Webster
MGI:108075  MGI:2176172  MP:0002082 postnatal lethality PMID: 16571625 
Isl1+|Isl1tm1(cre)Sev|Smotm1Amc|Smotm2Amc Isl1tm1(cre)Sev/Isl1+,Smotm1Amc/Smotm2Amc
involves: 129X1/SvJ
MGI:101791  MGI:108075  MP:0004158 right aortic arch PMID: 16687132 
Smotm1Amc|Smotm2Amc|Tg(Col2a1-cre)10Amc Smotm1Amc/Smotm2Amc,Tg(Col2a1-cre)10Amc/0
involves: 129X1/SvJ
MGI:108075  MGI:2176261  MP:0002765 short fibula PMID: 11748145 
Smotm1Amc|Smotm2Amc|Tg(Col2a1-cre)10Amc Smotm1Amc/Smotm2Amc,Tg(Col2a1-cre)10Amc/0
involves: 129X1/SvJ
MGI:108075  MGI:2176261  MP:0004351 short humerus PMID: 11748145 
Smotm1Amc|Smotm2Amc|Tg(Col2a1-cre)10Amc Smotm1Amc/Smotm2Amc,Tg(Col2a1-cre)10Amc/0
involves: 129X1/SvJ
MGI:108075  MGI:2176261  MP:0004340 short scapula PMID: 11748145 
Smotm1Amc|Smotm2Amc|Tg(Col2a1-cre)10Amc Smotm1Amc/Smotm2Amc,Tg(Col2a1-cre)10Amc/0
involves: 129X1/SvJ
MGI:108075  MGI:2176261  MP:0002764 short tibia PMID: 11748145 
Smotm1Amc|Smotm2Amc|Tg(Col2a1-cre)10Amc Smotm1Amc/Smotm2Amc,Tg(Col2a1-cre)10Amc/0
involves: 129X1/SvJ
MGI:108075  MGI:2176261  MP:0004359 short ulna PMID: 11748145 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0003108 short zygomatic bone PMID: 15107405 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0004459 small alisphenoid bone PMID: 15107405 
Smotm1Amc|Smotm2Amc|Tg(Nes-cre)1Kln Smotm1Amc/Smotm2Amc,Tg(Nes-cre)1Kln/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL * Swiss Webster
MGI:108075  MGI:2176172  MP:0000852 small cerebellum PMID: 16571625 
En1tm2(cre)Wrst|Gli3tm1Alj|Smotm2Amc En1tm2(cre)Wrst/?,Gli3tm1Alj/Gli3tm1Alj,Smotm2Amc/Smotm2Amc
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MGI:108075  MGI:95389  MGI:95729  MP:0000852 small cerebellum PMID: 18480159 
Smotm1Amc|Smotm2Amc|Tg(Wnt1-cre)11Rth Smotm1Amc/Smotm2Amc,Tg(Wnt1-cre)11Rth/?
involves: C57BL/6J * CBA/J
MGI:108075  MGI:2447280  MP:0004470 small nasal bone PMID: 15107405 
En1tm2(cre)Wrst|Gli3tm1Alj|Smotm2Amc En1tm2(cre)Wrst/?,Gli3tm1Alj/Gli3tm1Alj,Smotm2Amc/Smotm2Amc
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MGI:108075  MGI:95389  MGI:95729  MP:0000873 thin external granule cell layer PMID: 18480159 
Isl1+|Isl1tm1(cre)Sev|Smotm1Amc|Smotm2Amc Isl1tm1(cre)Sev/Isl1+,Smotm1Amc/Smotm2Amc
involves: 129X1/SvJ
MGI:101791  MGI:108075  MP:0004110 transposition of great arteries PMID: 16687132 
Isl1+|Isl1tm1(cre)Sev|Smotm1Amc|Smotm2Amc Isl1tm1(cre)Sev/Isl1+,Smotm1Amc/Smotm2Amc
involves: 129X1/SvJ
MGI:101791  MGI:108075  MP:0010402 ventricular septal defect PMID: 16687132 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Basal cell carcinoma
Disease Ontology: DOID:2513
References:  16
Click column headers to sort
Type Species Amino acid change Nucleotide change Description Reference
Missense Human W535L Activating mutation 16
Missense Human R562Q Activating mutation 16
Biologically Significant Variants
Type:  Point mutation
Species:  Mouse
Description:  An oncogenic point mutation has been identified in the mouse Smo gene.
References:  4

References

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1. AstraZeneca. AZD8542. Accessed on 12/09/2014. Modified on 12/09/2014. astrazeneca.com, http://openinnovation.astrazeneca.com/what-we-offer/compound/azd8542/

2. Corcoran RB, Scott MP. (2006) Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells. Proc Natl Acad Sci U S A103: 8408-8413. [PMID:16707575]

3. Kasai K, Takahashi M, Osumi N, Sinnarajah S, Takeo T, Ikeda H, Kehrl JH, Itoh G, Arnheiter H. (2004) The G12 family of heterotrimeric G proteins and Rho GTPase mediate Sonic hedgehog signalling. Genes Cells9: 49-58. [PMID:14723707]

4. Mao J, Ligon KL, Rakhlin EY, Thayer SP, Bronson RT, Rowitch D, McMahon AP. (2006) A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. Cancer Res66: 10171-10178. [PMID:17047082]

5. Masdeu C, Faure H, Coulombe J, Schoenfelder A, Mann A, Brabet I, Pin JP, Traiffort E, Ruat M. (2006) Identification and characterization of Hedgehog modulator properties after functional coupling of Smoothened to G15. Biochem Biophys Res Commun349: 471-479. [PMID:16945339]

6. Meloni AR, Fralish GB, Kelly P, Salahpour A, Chen JK, Wechsler-Reya RJ, Lefkowitz RJ, Caron MG. (2006) Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2. Mol Cell Biol26: 7550-7560. [PMID:16908539]

7. Munchhof MJ, Li Q, Shavnya A, Borzillo GV, Boyden TL, Jones CS, LaGreca SD, Martinez-Alsina L, Patel N, Pelletier K et al.. (2012) Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened. ACS Med Chem Lett3 (2): 106-11. [PMID:24900436]

8. Ohashi T, Oguro Y, Tanaka T, Shiokawa Z, Tanaka Y, Shibata S, Sato Y, Yamakawa H, Hattori H, Yamamoto Y et al.. (2012) Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: modification of the core skeleton for improved solubility. Bioorg. Med. Chem.20 (18): 5507-17. [PMID:22898254]

9. Riobo NA, Saucy B, Dilizio C, Manning DR. (2006) Activation of heterotrimeric G proteins by Smoothened. Proc Natl Acad Sci U S A103: 12607-12612. [PMID:16885213]

10. Stone DM, Hynes M, Armanini M, Swanson TA, Gu Q, Johnson RL, Scott MP, Pennica D, Goddard A, Phillips H, Noll M, Hooper JE, de Sauvage F, Rosenthal A. (1996) The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature384: 129-134. [PMID:8906787]

11. Taipale J, Chen JK, Cooper MK, Wang B, Mann RK, Milenkovic L, Scott MP, Beachy PA. (2000) Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature406: 1005-1009. [PMID:10984056]

12. Traiffort E, Charytoniuk DA, Faure H, Ruat M. (1998) Regional distribution of Sonic Hedgehog, patched, and smoothened mRNA in the adult rat brain. J Neurochem70: 1327-1330. [PMID:9489757]

13. Tremblay MR, Lescarbeau A, Grogan MJ, Tan E, Lin G, Austad BC, Yu LC, Behnke ML, Nair SJ, Hagel M et al.. (2009) Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926). J. Med. Chem.52 (14): 4400-18. [PMID:19522463]

14. Wang C, Wu H, Katritch V, Han GW, Huang XP, Liu W, Siu FY, Roth BL, Cherezov V, Stevens RC. (2013) Structure of the human smoothened receptor bound to an antitumour agent. Nature,  [Epub ahead of print]. [PMID:23636324]

15. Wang J, Mook Jr RA, Lu J, Gooden DM, Ribeiro A, Guo A, Barak LS, Lyerly HK, Chen W. (2012) Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling. Bioorg. Med. Chem.20 (22): 6751-7. [PMID:23063522]

16. Xie J, Murone M, Luoh SM, Ryan A, Gu Q, Zhang C, Bonifas JM, Lam CW, Hynes M, Goddard A, Rosenthal A, Epstein EH, de Sauvage FJ. (1998) Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature391: 90-92. [PMID:9422511]

17. Zhang X, Zhao F, Wu Y, Yang J, Han GW, Zhao S, Ishchenko A, Ye L, Lin X, Ding K et al.. (2017) Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand. Nat Commun8: 15383. [PMID:28513578]

18. Zhang XM, Ramalho-Santos M, McMahon AP. (2001) Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node. Cell105: 781-792. [PMID:11440720]

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Gunnar Schulte, Jacomijn Dijksterhuis, Julian Petersen, Elisa Arthofer, Belma Hot, Katerina Strakova, Shane Wright, Jana Valnohova, Matthias Lauth.
Class Frizzled GPCRs: SMO. Last modified on 19/05/2017. Accessed on 11/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=239.