plasminogen activator, tissue type

Target id: 2392

Nomenclature: plasminogen activator, tissue type

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for plasminogen activator, tissue type in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 562 8p11.21 PLAT plasminogen activator, tissue type
Mouse - 559 8 A2 Plat plasminogen activator, tissue
Rat - 559 16q12.5 Plat plasminogen activator, tissue type
Previous and Unofficial Names
PATISS | tPA | plasminogen activator
Database Links
Specialist databases
MEROPS S01.232 (Hs)
Other databases
BRENDA
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.21.68

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
Dup-714 Hs Inhibition 8.2 pKi 1
pKi 8.2 (Ki 5.7x10-9 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Hyperfibrinolysis, familial, due to increased release of tissue plasminogen activator
OMIM: 612348

References

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1. Galemmo RA Jr., Fevig JM, Carini DJ, Cacciola J, Wells BL, Hillyer GL, Buriak J Jr., Rossi KA, Stouten PFW, Alexander RS et al.. (1996) (N-acyl-N-alkyl)glycyl borolysine analogs: A new class of potent thrombin inhibitors. Bioorganic & Medicinal Chemistry Letters6 (24): 2913–2918.

How to cite this page

S1: Chymotrypsin: plasminogen activator, tissue type. Last modified on 29/01/2016. Accessed on 22/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2392.