plasminogen

Target id: 2394

Nomenclature: plasminogen

Family: S1: Chymotrypsin

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for plasminogen in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 810 6q26 PLG plasminogen
Mouse - 812 17 A1 Plg plasminogen
Rat - 812 1q11 Plg plasminogen
Previous and Unofficial Names
angiostatin | Pg
Database Links
Specialist databases
MEROPS S01.233 (Hs)
Other databases
BRENDA
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.21.7

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
bis-triazole derivative 10 Hs Inhibition 9.1 pKi 2
pKi 9.1 (Ki 7.7x10-10 M) [2]
aprotinin {Sp: Bovine} Hs Binding 6.8 pIC50 3
pIC50 6.8 (IC50 1.6x10-7 M) [3]
6-aminocaproic acid Hs Binding 4.4 pIC50 1
pIC50 4.4 (IC50 4x10-5 M) [1]
Description: Measuring inhibition of fibrinolysis in plasma.
tranexamic acid Hs Binding 3.6 pIC50 3
pIC50 3.6 (IC50 2.41x10-4 M) [3]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Hypoplasminogenemia
Synonyms: Plasminogen deficiency type 1
OMIM: 217090
Orphanet: ORPHA722
Disease:  Ligneous conjunctivitis
OMIM: 217090
Orphanet: ORPHA97231

References

Show »

1. Cheng L, Pettersen D, Ohlsson B, Schell P, Karle M, Evertsson E, Pahlen S, Jonforsen M, Plowright AT, Bostrom J et al.. (2014) Discovery of the Fibrinolysis Inhibitor AZD6564, Acting via Interference of a Protein-Protein Interaction. ACS Med Chem Lett5 (5): 538-543. [PMID:24900876]

2. Saupe SM, Steinmetzer T. (2012) A new strategy for the development of highly potent and selective plasmin inhibitors. J. Med. Chem.55 (3): 1171-80. [PMID:22276953]

3. Sperzel M, Huetter J. (2007) Evaluation of aprotinin and tranexamic acid in different in vitro and in vivo models of fibrinolysis, coagulation and thrombus formation. J. Thromb. Haemost.5 (10): 2113-8. [PMID:17666018]

How to cite this page

S1: Chymotrypsin: plasminogen. Last modified on 07/09/2015. Accessed on 24/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2394.