prolyl endopeptidase

Target id: 2395

Nomenclature: prolyl endopeptidase

Family: S9: Prolyl oligopeptidase

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for prolyl endopeptidase in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 710 6q22 PREP prolyl endopeptidase
Mouse - 710 10 B2-B3 Prep prolyl endopeptidase
Rat - 710 20q13 Prep prolyl endopeptidase
Previous and Unofficial Names
PE | PEP | Pop | post-proline cleaving enzyme
Database Links
Specialist databases
MEROPS S09.001 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.21.26

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
S 17092 Hs Inhibition 8.8 pKi 1
pKi 8.8 (Ki 1.5x10-9 M) [1]
ARI-3531 Hs Inhibition 8.9 pIC50 2
pIC50 8.9 (IC50 1.3x10-9 M) [2]

References

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1. Lawandi J, Gerber-Lemaire S, Juillerat-Jeanneret L, Moitessier N. (2010) Inhibitors of prolyl oligopeptidases for the therapy of human diseases: defining diseases and inhibitors. J. Med. Chem.53 (9): 3423-38. [PMID:20058865]

2. Poplawski SE, Lai JH, Li Y, Jin Z, Liu Y, Wu W, Wu Y, Zhou Y, Sudmeier JL, Sanford DG et al.. (2013) Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase. J. Med. Chem.56 (9): 3467-77. [PMID:23594271]

How to cite this page

S9: Prolyl oligopeptidase: prolyl endopeptidase. Last modified on 14/07/2015. Accessed on 17/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2395.