protein C, inactivator of coagulation factors Va and VIIIa

Target id: 2396

Nomenclature: protein C, inactivator of coagulation factors Va and VIIIa

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

This target is also described as a ligand entry: protein Cprotein Cprotein C

   GtoImmuPdb view: OFF :     Currently no data for protein C, inactivator of coagulation factors Va and VIIIa in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 461 2q13-q14 PROC protein C, inactivator of coagulation factors Va and VIIIa
Mouse - 481 18 B3 Proc protein C
Rat - 461 18p12 Proc protein C, inactivator of coagulation factors Va and VIIIa
Previous and Unofficial Names
anticoagulant protein C | autoprothrombin IIA | PC | vitamin K-dependent protein C | blood coagulation factor XIV | protein C (inactivator of coagulation factors Va and VIIIa)
Database Links
Specialist databases
MEROPS S01.218 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.21.69

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 37 [PMID: 24418773] Hs Inhibition 7.4 pKi 1
pKi 7.4 (Ki 4x10-8 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Thrombophilia due to protein C deficiency, autosomal dominant
Synonyms: Hereditary thrombophilia due to congenital protein C deficiency [Orphanet: ORPHA745]
Thrombophilia [Disease Ontology: DOID:2452]
Disease Ontology: DOID:2452
OMIM: 176860
Orphanet: ORPHA745
Disease:  Thrombophilia due to protein C deficiency, autosomal recessive
Synonyms: Hereditary thrombophilia due to congenital protein C deficiency [Orphanet: ORPHA745]
Thrombophilia [Disease Ontology: DOID:2452]
Disease Ontology: DOID:2452
OMIM: 612304
Orphanet: ORPHA745

References

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1. Bach P, Knerr L, Fjellström O, Hansson K, Mattsson C, Gustafsson D. (2014) Design, synthesis, and SAR of a series of activated protein C (APC) inhibitors with selectivity against thrombin for the treatment of haemophilia. Bioorg. Med. Chem. Lett., 24 (3): 821-7. [PMID:24418773]

How to cite this page

S1: Chymotrypsin: protein C, inactivator of coagulation factors Va and VIIIa. Last modified on 29/01/2016. Accessed on 20/06/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2396.