protein C, inactivator of coagulation factors Va and VIIIa

Target id: 2396

Nomenclature: protein C, inactivator of coagulation factors Va and VIIIa

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

This target is also described as a ligand entry: protein Cprotein Cprotein C

   GtoImmuPdb view: OFF :     Currently no data for protein C, inactivator of coagulation factors Va and VIIIa in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 461 2q13-q14 PROC protein C, inactivator of coagulation factors Va and VIIIa
Mouse - 481 18 B3 Proc protein C
Rat - 461 18p12 Proc protein C
Previous and Unofficial Names
anticoagulant protein C | autoprothrombin IIA | PC | vitamin K-dependent protein C | blood coagulation factor XIV | protein C (inactivator of coagulation factors Va and VIIIa)
Database Links
Specialist databases
MEROPS S01.218 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.21.69

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 37 [PMID: 24418773] Hs Inhibition 7.4 pKi 1
pKi 7.4 (Ki 4x10-8 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Thrombophilia due to protein C deficiency, autosomal dominant
Synonyms: Hereditary thrombophilia due to congenital protein C deficiency [Orphanet: ORPHA745]
Thrombophilia [Disease Ontology: DOID:2452]
Disease Ontology: DOID:2452
OMIM: 176860
Orphanet: ORPHA745
Disease:  Thrombophilia due to protein C deficiency, autosomal recessive
Synonyms: Hereditary thrombophilia due to congenital protein C deficiency [Orphanet: ORPHA745]
Thrombophilia [Disease Ontology: DOID:2452]
Disease Ontology: DOID:2452
OMIM: 612304
Orphanet: ORPHA745

References

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1. Bach P, Knerr L, Fjellström O, Hansson K, Mattsson C, Gustafsson D. (2014) Design, synthesis, and SAR of a series of activated protein C (APC) inhibitors with selectivity against thrombin for the treatment of haemophilia. Bioorg. Med. Chem. Lett.24 (3): 821-7. [PMID:24418773]

How to cite this page

S1: Chymotrypsin: protein C, inactivator of coagulation factors Va and VIIIa. Last modified on 29/01/2016. Accessed on 13/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2396.