serine protease 8 | S1: Chymotrypsin | IUPHAR/BPS Guide to PHARMACOLOGY

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serine protease 8

Target not currently curated in GtoImmuPdb

Target id: 2400

Nomenclature: serine protease 8

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 343 16p11.2 PRSS8 serine protease 8
Mouse - 341 7 F3 Prss8 protease, serine 8 (prostasin)
Rat - 342 1q36 Prss8 serine protease 8
Previous and Unofficial Names
CAP1 | channel activating protease 1 | prostasin | protease, serine, 8 (prostasin) | protease | protease, serine 8 (prostasin) | protease, serine 8
Database Links
Specialist databases
MEROPS S01.159 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.21.-

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
B3C Hs Inhibition 7.9 pKi 1
pKi 7.9 (Ki 1.2x10-8 M) [1]

References

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1. Tully DC, Vidal A, Chatterjee AK, Williams JA, Roberts MJ, Petrassi HM, Spraggon G, Bursulaya B, Pacoma R, Shipway A et al.. (2008) Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design. Bioorg. Med. Chem. Lett., 18 (22): 5895-9. [PMID:18752942]

How to cite this page

S1: Chymotrypsin: serine protease 8. Last modified on 27/02/2018. Accessed on 19/06/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2400.