proteasome subunit beta 1

Target id: 2404

Nomenclature: proteasome subunit beta 1

Family: T1: Proteasome

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for proteasome subunit beta 1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 241 6q27 PSMB1 proteasome subunit beta 1
Mouse - 240 17 A2 Psmb1 proteasome (prosome, macropain) subunit, beta type 1
Rat - 240 1q12 Psmb1 proteasome subunit beta 1
Previous and Unofficial Names
component C5 of proteasome | HC5 | Lmpc5 | macropain subunit C5 | PMSB1 | proteasome gamma chain | proteasome subunit C5 | multicatalytic endopeptidase complex subunit C5 | proteasome (prosome, macropain) subunit, beta type 1 | proteasome (prosome, macropain) subunit, beta type, 1
Database Links
Specialist databases
MEROPS T01.986 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.25.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 3b [PMID: 24946214] Hs Inhibition 6.6 pKi 1
pKi 6.6 (Ki 2.4x10-7 M) [1]

References

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1. Troiano V, Scarbaci K, Ettari R, Micale N, Cerchia C, Pinto A, Schirmeister T, Novellino E, Grasso S, Lavecchia A et al.. (2014) Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors. Eur J Med Chem83: 1-14. [PMID:24946214]

How to cite this page

T1: Proteasome: proteasome subunit beta 1. Last modified on 15/10/2015. Accessed on 18/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2404.