proteasome subunit beta 1

Target id: 2404

Nomenclature: proteasome subunit beta 1

Family: T1: Proteasome

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for proteasome subunit beta 1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 241 6q27 PSMB1 proteasome subunit beta 1
Mouse - 240 17 A2 Psmb1 proteasome (prosome, macropain) subunit, beta type 1
Rat - 240 1q12 Psmb1 proteasome subunit beta 1
Previous and Unofficial Names
component C5 of proteasome | HC5 | Lmpc5 | macropain subunit C5 | PMSB1 | proteasome gamma chain | proteasome subunit C5 | multicatalytic endopeptidase complex subunit C5 | proteasome (prosome, macropain) subunit, beta type 1 | proteasome (prosome, macropain) subunit, beta type, 1 | proteasome (prosome
Database Links
Specialist databases
MEROPS T01.986 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.25.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 3b [PMID: 24946214] Hs Inhibition 6.6 pKi 1
pKi 6.6 (Ki 2.4x10-7 M) [1]

References

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1. Troiano V, Scarbaci K, Ettari R, Micale N, Cerchia C, Pinto A, Schirmeister T, Novellino E, Grasso S, Lavecchia A et al.. (2014) Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors. Eur J Med Chem, 83: 1-14. [PMID:24946214]

How to cite this page

T1: Proteasome: proteasome subunit beta 1. Last modified on 15/10/2015. Accessed on 20/06/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2404.