Ras converting CAAX endopeptidase 1

Target id: 2412

Nomenclature: Ras converting CAAX endopeptidase 1

Family: M79: Prenyl protease 2

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Ras converting CAAX endopeptidase 1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 329 11q13 RCE1 Ras converting CAAX endopeptidase 1
Mouse - 329 19 A Rce1 Ras converting CAAX endopeptidase 1
Rat - 329 1q42 Rce1 Ras converting CAAX endopeptidase 1
Previous and Unofficial Names
CAAX prenyl protease 2 | FACE2 | prenyl protein-specific endoprotease 2 | Ras and a-factor-converting enzyme 1 homolog | RCE1A | RCE1B | farnesylated protein-converting enzyme 2 | RCE1 homolog, prenyl protein protease (S. cerevisiae) | RCE1 homolog, prenyl protein peptidase (S. cerevisiae)
Database Links
Specialist databases
MEROPS M79.002 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.22.-

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
CID16197121 Hs Inhibition 6.7 pIC50 1
pIC50 6.7 (IC50 1.86x10-7 M) Activity reported as AU50 [1]
compound 3 [PMID: 17942791] Hs Inhibition 5.1 pIC50 2
pIC50 5.1 (IC50 9x10-6 M) [2]

References

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1. Broad Institute. Human Ras-Converting Enzyme Inhibition Assay AID 588849. Accessed on 15/07/2015. Modified on 15/07/2015. PubChemBioAssay, https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=588849

2. Manandhar SP, Hildebrandt ER, Schmidt WK. (2007) Small-molecule inhibitors of the Rce1p CaaX protease. J Biomol Screen12 (7): 983-93. [PMID:17942791]

How to cite this page

M79: Prenyl protease 2: Ras converting CAAX endopeptidase 1. Last modified on 15/07/2015. Accessed on 20/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2412.