renin | A1: Pepsin | IUPHAR/BPS Guide to PHARMACOLOGY

renin

Target id: 2413

Nomenclature: renin

Family: A1: Pepsin

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for renin in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 406 1q32 REN renin
Mouse - 402 1 E4 Ren1 renin 1 structural
Rat - 402 13q13 Ren renin
Previous and Unofficial Names
angiotensinogenase | aspartyl-protease | kidney renin | Ren1 | Ren-A | RENAA | renin b | Rnr
Database Links
Specialist databases
MEROPS A01.007 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.23.15

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
aliskiren Hs Inhibition 9.2 pIC50 1
pIC50 9.2 (IC50 6x10-10 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Hyperuricemic nephropathy, familial juvenile 2; HNFJ2
Synonyms: Familial juvenile hyperuricemic nephropathy [Disease Ontology: DOID:0060062]
Hyperuricemia - anemia - renal failure [Orphanet: ORPHA217330]
Disease Ontology: DOID:0060062
OMIM: 613092
Orphanet: ORPHA217330
Disease:  Renal tubular dysgenesis
OMIM: 267430
Orphanet: ORPHA97369

References

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1. Wuerzner G, Azizi M. (2008) Renin inhibition with aliskiren. Clin. Exp. Pharmacol. Physiol., 35 (4): 426-30. [PMID:18307734]

How to cite this page

A1: Pepsin: renin. Last modified on 13/03/2014. Accessed on 14/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2413.