squalene monooxygenase | Lanosterol biosynthesis pathway | IUPHAR/BPS Guide to PHARMACOLOGY

squalene monooxygenase

Target id: 2433

Nomenclature: squalene monooxygenase

Family: Lanosterol biosynthesis pathway

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for squalene monooxygenase in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 574 8q24.1 SQLE squalene epoxidase 3
Mouse - 572 15 25.16cM Sqle squalene epoxidase
Rat - 573 7q33 Sqle squalene epoxidase
Previous and Unofficial Names
SE | squalene epoxidase
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.14.13.132 H+ + NADPH + O2 + squalene = H2O + NADP+ + (S)-2,3-epoxysqualene
Cofactors
Cofactor Species Comments Reference
flavin adenine dinucleotide Human 2

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 1b [PMID: 9871762] Hs Inhibition 7.2 pIC50 1
pIC50 7.2 (IC50 6x10-8 M) [1]
Tissue Distribution
Liver
Species:  Human
Technique:  PCR
References:  2

References

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1. Gotteland JP, Loubat C, Planty B, Junquéro D, Delhon A, Halazy S. (1998) Sulfonamide derivatives of benzylamine block cholesterol biosynthesis in HepG2 cells: a new type of potent squalene epoxidase inhibitors. Bioorg. Med. Chem. Lett., 8 (11): 1337-42. [PMID:9871762]

2. Laden BP, Tang Y, Porter TD. (2000) Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase. Arch. Biochem. Biophys., 374 (2): 381-8. [PMID:10666321]

3. Nagai M, Sakakibara J, Wakui K, Fukushima Y, Igarashi S, Tsuji S, Arakawa M, Ono T. (1997) Localization of the squalene epoxidase gene (SQLE) to human chromosome region 8q24.1. Genomics, 44 (1): 141-3. [PMID:9286711]

Contributors

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How to cite this page

Helen E. Benson.
Lanosterol biosynthesis pathway: squalene monooxygenase. Last modified on 10/07/2018. Accessed on 15/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2433.