alkaline ceramidase 1

Target id: 2468

Nomenclature: alkaline ceramidase 1

Family: Alkaline ceramidases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     alkaline ceramidase 1 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 264 19p13.3 ACER1 alkaline ceramidase 1
Mouse 7 273 17 D Acer1 alkaline ceramidase 1
Rat - 273 9q11 Acer1 alkaline ceramidase 1
Previous and Unofficial Names
Acylsphingosine deacylase 3 | Alkaline CDase 1 | AlkCDase 1 | ASAH3 | Cer1
Database Links
BRENDA
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.5.1.23 ceramide -> sphingosine + a fatty acid
Immunopharmacology Comments
The major biological role of ACER1 is that of maintaining skin homeostasis via regulation of keratinocyte differentiation [1]. ACER1 is included in GtoImmuPdb because of its involvement in generating the sphingolipid sphingosine, which is subsequently phosphorylated (by sphingosine kinase) to the bioactive lipid mediator S1P [3]. S1P is a major regulator of the vascular and immune systems. In the immune system S1P activation of its receptor S1P1R promotes trafficking of T and B cells from the lymphoid organs into the lymphatic vessels.
Tissue Distribution
Human epidermal keratinocytes
Species:  Human
Technique:  In situ hybridization, RT-PCR.
References:  2

References

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1. Coant N, Sakamoto W, Mao C, Hannun YA. (2017) Ceramidases, roles in sphingolipid metabolism and in health and disease. Adv Biol Regul63: 122-131. [PMID:27771292]

2. Houben E, Holleran WM, Yaginuma T, Mao C, Obeid LM, Rogiers V, Takagi Y, Elias PM, Uchida Y. (2006) Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis. J. Lipid Res.47 (5): 1063-70. [PMID:16477081]

3. Mao C, Xu R, Szulc ZM, Bielawski J, Becker KP, Bielawska A, Galadari SH, Hu W, Obeid LM. (2003) Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides. J. Biol. Chem.278 (33): 31184-91. [PMID:12783875]

How to cite this page

Alkaline ceramidases: alkaline ceramidase 1. Last modified on 21/03/2017. Accessed on 14/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2468.