alkaline ceramidase 3 | Alkaline ceramidases | IUPHAR/BPS Guide to PHARMACOLOGY

alkaline ceramidase 3

Target id: 2470

Nomenclature: alkaline ceramidase 3

Family: Alkaline ceramidases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     alkaline ceramidase 3 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 267 11q13.5 ACER3 alkaline ceramidase 3
Mouse - 267 7 E2 Acer3 alkaline ceramidase 3
Rat - 267 1q32 Acer3 alkaline ceramidase 3
Previous and Unofficial Names
Alkaline CDase 3 | AlkCDase 3 | phytoceramidase, alkaline | Alkaline phytoceramidase
Database Links
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.5.1.-
Immunopharmacology Comments
ACER3 may play a role in inflammation, since it is reported that loss of Acer3 in mice aggravates colitis and colitis-associated colorectal cancer [1]. This effect is thought to be the result of accumulation of the ACER3 substrate C18:1-ceramide, which potentiates LPS-induced production of pro-inflammatory cytokines in mouse immune cells.

References

Show »

1. Wang K, Xu R, Snider AJ, Schrandt J, Li Y, Bialkowska AB, Li M, Zhou J, Hannun YA, Obeid LM et al.. (2016) Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system. Cell Death Dis, 7: e2124. [PMID:26938296]

How to cite this page

Alkaline ceramidases: alkaline ceramidase 3. Last modified on 21/03/2017. Accessed on 25/09/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2470.