alkaline ceramidase 3

Target id: 2470

Nomenclature: alkaline ceramidase 3

Family: Alkaline ceramidases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     alkaline ceramidase 3 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 267 11q13.5 ACER3 alkaline ceramidase 3
Mouse - 267 7 E2 Acer3 alkaline ceramidase 3
Rat - 267 1q32 Acer3 alkaline ceramidase 3
Previous and Unofficial Names
Alkaline CDase 3 | AlkCDase 3 | phytoceramidase, alkaline | Alkaline phytoceramidase
Database Links
BRENDA
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.5.1.-
Immunopharmacology Comments
ACER3 may play a role in inflammation, since it is reported that loss of Acer3 in mice aggravates colitis and colitis-associated colorectal cancer [1]. This effect is thought to be the result of accumulation of the ACER3 substrate C18:1-ceramide, which potentiates LPS-induced production of pro-inflammatory cytokines in mouse immune cells.

References

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1. Wang K, Xu R, Snider AJ, Schrandt J, Li Y, Bialkowska AB, Li M, Zhou J, Hannun YA, Obeid LM et al.. (2016) Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system. Cell Death Dis7: e2124. [PMID:26938296]

How to cite this page

Alkaline ceramidases: alkaline ceramidase 3. Last modified on 21/03/2017. Accessed on 12/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2470.