choline O-acetyltransferase

Target id: 2480

Nomenclature: choline O-acetyltransferase

Abbreviated Name: ChAT

Family: Acetylcholine turnover

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for choline O-acetyltransferase in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 748 10q11.2 CHAT choline O-acetyltransferase
Mouse - 641 14 B Chat choline acetyltransferase
Rat - 640 16p16 Chat choline O-acetyltransferase
Previous and Unofficial Names
CHOACTase | Choline acetylase
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.3.1.6 Acetyl CoA + choline = acetylcholine + coenzyme A

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 2 [PMID: 3351860] Mm Inhibition 6.5 pIC50 1
pIC50 6.5 (IC50 3.4x10-7 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Myasthenic syndrome, congenital, 6, presynaptic; CMS6
Synonyms: Congenital myasthenic syndrome [Disease Ontology: DOID:3635] [Orphanet: ORPHA590]
Presynaptic congenital myasthenic syndromes [Orphanet: ORPHA98914]
Disease Ontology: DOID:3635
OMIM: 254210
Orphanet: ORPHA98914, ORPHA590

References

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1. Gray AP, Platz RD, Henderson TR, Chang TC, Takahashi K, Dretchen KL. (1988) Approaches to protection against nerve agent poisoning. (Naphthylvinyl)pyridine derivatives as potential antidotes. J. Med. Chem.31 (4): 807-14. [PMID:3351860]

How to cite this page

Acetylcholine turnover: choline O-acetyltransferase. Last modified on 18/09/2015. Accessed on 21/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2480.