choline O-acetyltransferase

Target id: 2480

Nomenclature: choline O-acetyltransferase

Abbreviated Name: ChAT

Family: Acetylcholine turnover

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for choline O-acetyltransferase in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 748 10q11.2 CHAT choline O-acetyltransferase
Mouse - 641 14 B Chat choline acetyltransferase
Rat - 640 16p16 Chat choline O-acetyltransferase
Previous and Unofficial Names
CHOACTase | Choline acetylase
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.3.1.6 Acetyl CoA + choline = acetylcholine + coenzyme A

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 2 [PMID: 3351860] Mm Inhibition 6.5 pIC50 1
pIC50 6.5 (IC50 3.4x10-7 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Myasthenic syndrome, congenital, 6, presynaptic; CMS6
Synonyms: Congenital myasthenic syndrome [Disease Ontology: DOID:3635] [Orphanet: ORPHA590]
Presynaptic congenital myasthenic syndromes [Orphanet: ORPHA98914]
Disease Ontology: DOID:3635
OMIM: 254210
Orphanet: ORPHA98914, ORPHA590

References

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1. Gray AP, Platz RD, Henderson TR, Chang TC, Takahashi K, Dretchen KL. (1988) Approaches to protection against nerve agent poisoning. (Naphthylvinyl)pyridine derivatives as potential antidotes. J. Med. Chem., 31 (4): 807-14. [PMID:3351860]

How to cite this page

Acetylcholine turnover: choline O-acetyltransferase. Last modified on 18/09/2015. Accessed on 23/06/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2480.