Neutral sphingomyelinase coupling factors | Enzymes | IUPHAR/BPS Guide to PHARMACOLOGY

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Neutral sphingomyelinase coupling factors

Neutral sphingomyelinase coupling factors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Protein FAN [1] and polycomb protein EED [3] allow coupling between TNF receptors and neutral sphingomyelinase phosphodiesterases.

Enzymes

2495

embryonic ectoderm development C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2487

Nomenclature

embryonic ectoderm development

Previous and unofficial names

Polycomb protein EED | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1

Genes

EED (Hs), Eed (Mm), Eed (Rn)

Ensembl ID

ENSG00000074266 (Hs), ENSMUSG00000030619 (Mm), ENSRNOG00000017509 (Rn)

UniProtKB AC

O75530 (Hs), Q921E6 (Mm)

Selective inhibitors

A-395 (Binding) pK_i 9.4 [2]

neutral sphingomyelinase activation associated factor C Show summary »« Hide summary

Target Id	2495
Nomenclature	neutral sphingomyelinase activation associated factor
Previous and unofficial names	Factor associated with neutral sphingomyelinase activation \| FAN \| neutral sphingomyelinase (N-SMase) activation associated factor
Genes	NSMAF (Hs), Nsmaf (Mm), Nsmaf (Rn)
Ensembl ID	ENSG00000035681 (Hs), ENSMUSG00000028245 (Mm), ENSRNOG00000010234 (Rn)
UniProtKB AC	Q92636 (Hs), O35242 (Mm)

References

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1. Adam-Klages S, Adam D, Wiegmann K, Struve S, Kolanus W, Schneider-Mergener J, Krönke M. (1996) FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase. Cell, 86 (6): 937-47. [PMID:8808629]

2. He Y, Selvaraju S, Curtin ML, Jakob CG, Zhu H, Comess KM, Shaw B, The J, Lima-Fernandes E, Szewczyk MM et al.. (2017) The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nat Chem Biol, 13 (4): 389-395. [PMID:28135237]

3. Philipp S, Puchert M, Adam-Klages S, Tchikov V, Winoto-Morbach S, Mathieu S, Deerberg A, Kolker L, Marchesini N, Kabelitz D et al.. (2010) The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase. Proc Natl Acad Sci USA, 107 (3): 1112-7. [PMID:20080539]

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.