phosphoinositide-3-kinase regulatory subunit 1

Target id: 2503

Nomenclature: phosphoinositide-3-kinase regulatory subunit 1

Abbreviated Name: p85α/PIK3R1

Family: Phosphatidylinositol kinases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     phosphoinositide-3-kinase regulatory subunit 1 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 724 5q13.1 PIK3R1 phosphoinositide-3-kinase regulatory subunit 1
Mouse - 724 13 D1 Pik3r1 phosphoinositide-3-kinase regulatory subunit 1
Rat - 724 2q12 Pik3r1 phosphoinositide-3-kinase regulatory subunit 1
Previous and Unofficial Names
GRB1 | p50alpha | p55alpha | PI3K regulatory subunit alpha | PI3-kinase regulatory subunit alpha | PtdIns-3-kinase regulatory subunit alpha | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
Database Links
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Immunopharmacology Comments
p85α is included in GtoImmuPdb as it is the regulatory subunit of several PI3Ks (e.g. PI3Kδ and PI3Kγ) with roles in leukocyte biology and therefore important for immunity [2]. Mutations in the PIK3R1 gene that generate proteins incapable of interacting with the catalytic p110 PI3K subunits (and causes elevated p110 activity) are reported to cause human immunodeficiency [1].
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096) TAS
leukocyte migration (GO:0050900) TAS
References: 
Immuno Process:  Antigen presentation
Immuno Process ID:  3
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096) TAS
References: 
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  T cell costimulation (GO:0031295) TAS
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  T cell costimulation (GO:0031295) TAS
Fc-epsilon receptor signaling pathway (GO:0038095) TAS
Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096) TAS
negative regulation of osteoclast differentiation (GO:0045671) IEA
T cell receptor signaling pathway (GO:0050852) TAS
References: 
Immuno Process:  Chemotaxis & migration
Immuno Process ID:  10
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  T cell costimulation (GO:0031295) TAS
leukocyte migration (GO:0050900) TAS
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  B cell differentiation (GO:0030183) IEA
T cell costimulation (GO:0031295) TAS
Fc-epsilon receptor signaling pathway (GO:0038095) TAS
Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096) TAS
T cell receptor signaling pathway (GO:0050852) TAS
References: 
Immuno Process:  B cell (activation)
Immuno Process ID:  5
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  B cell differentiation (GO:0030183) IEA
References: 
Immuno Process:  Immune system development
Immuno Process ID:  8
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  B cell differentiation (GO:0030183) IEA
negative regulation of osteoclast differentiation (GO:0045671) IEA
References: 
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of tumor necrosis factor production (GO:0032760) IEA
interleukin-7-mediated signaling pathway (GO:0038111) TAS
References: 

References

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1. Deau MC, Heurtier L, Frange P, Suarez F, Bole-Feysot C, Nitschke P, Cavazzana M, Picard C, Durandy A, Fischer A et al.. (2014) A human immunodeficiency caused by mutations in the PIK3R1 gene. J. Clin. Invest.124 (9): 3923-8. [PMID:25133428]

2. Lucas CL, Chandra A, Nejentsev S, Condliffe AM, Okkenhaug K. (2016) PI3Kδ and primary immunodeficiencies. Nat. Rev. Immunol.16 (11): 702-714. [PMID:27616589]

How to cite this page

Phosphatidylinositol kinases: phosphoinositide-3-kinase regulatory subunit 1. Last modified on 19/04/2017. Accessed on 13/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2503.