serine palmitoyltransferase long chain base subunit 1

Target id: 2509

Nomenclature: serine palmitoyltransferase long chain base subunit 1

Abbreviated Name: SPT1

Family: Serine palmitoyltransferase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for serine palmitoyltransferase long chain base subunit 1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 473 9q22.31 SPTLC1 serine palmitoyltransferase long chain base subunit 1
Mouse - 473 13 B1 Sptlc1 serine palmitoyltransferase, long chain base subunit 1
Rat - 473 17p14 Sptlc1 serine palmitoyltransferase, long chain base subunit 1
Previous and Unofficial Names
hereditary sensory neuropathy, type 1 | HSN1 | LCB1 | Serine-palmitoyl-CoA transferase 1 | SPTI | serine palmitoyltransferase, long chain base subunit 1 | serine palmitoyltransferase
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.3.1.50 L-serine + palmitoyl-CoA -> 3-ketosphinganine + coenzyme A + CO2
Cofactors
Cofactor Species Comments Reference
pyridoxal phosphate Human

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
myriocin Mm Inhibition 9.6 pKi 1
pKi 9.6 (Ki 2.8x10-10 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Neuropathy, hereditary sensory and autonomic, type IA; HSAN1A
Synonyms: Hereditary sensory and autonomic neuropathy [Disease Ontology: DOID:11533]
Hereditary sensory and autonomic neuropathy type 1 [Orphanet: ORPHA36386]
Disease Ontology: DOID:11533
OMIM: 162400
Orphanet: ORPHA36386

References

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1. Miyake Y, Kozutsumi Y, Nakamura S, Fujita T, Kawasaki T. (1995) Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin. Biochem. Biophys. Res. Commun.211 (2): 396-403. [PMID:7794249]

How to cite this page

Serine palmitoyltransferase: serine palmitoyltransferase long chain base subunit 1. Last modified on 29/01/2016. Accessed on 17/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2509.