Sphingomyelin synthase | Enzymes | IUPHAR/BPS Guide to PHARMACOLOGY

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Ceramide turnover
Sphingomyelin synthase

Sphingomyelin synthase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Following translocation from the ER to the Golgi under the influence of the ceramide transfer protein, sphingomyelin synthases allow the formation of sphingomyelin by the transfer of phosphocholine from the phospholipid phosphatidylcholine.

Sphingomyelin synthase-related protein 1 is structurally related but lacks sphingomyelin synthase activity.

Enzymes

2525

sphingomyelin synthase 1 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2520

Nomenclature

sphingomyelin synthase 1

Previous and unofficial names

Phosphatidylcholine:ceramide cholinephosphotransferase 1 | Protein Mob | SMS1 | TMEM23 | transmembrane protein 23

Genes

SGMS1 (Hs), Sgms1 (Mm), Sgms1 (Rn)

Ensembl ID

ENSG00000198964 (Hs), ENSMUSG00000040451 (Mm), ENSRNOG00000012536 (Rn)

UniProtKB AC

Q86VZ5 (Hs), Q8VCQ6 (Mm), Q7TSX5 (Rn)

EC number

2.7.8.27

ceramide + phosphatidylcholine -> sphingomyelin + diacylglycerol

Inhibitors

compound 1j [PMID: 26314925] pIC₅₀ 5.7 [2]

sphingomyelin synthase 2 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2521

Nomenclature

sphingomyelin synthase 2

Previous and unofficial names

Phosphatidylcholine:ceramide cholinephosphotransferase 2 | SMS2

Genes

SGMS2 (Hs), Sgms2 (Mm), Sgms2 (Rn)

Ensembl ID

ENSG00000164023 (Hs), ENSMUSG00000050931 (Mm), ENSRNOG00000011284 (Rn)

UniProtKB AC

Q8NHU3 (Hs), Q9D4B1 (Mm), Q4JM44 (Rn)

EC number

2.7.8.27

ceramide + phosphatidylcholine -> sphingomyelin + diacylglycerol

Inhibitors

compound D24 [PMID: 24374347] pIC₅₀ 4.9 [1]

Comment

Palmitoylation of sphingomyelin synthase 2 may allow targeting to the plasma membrane [3].

sterile alpha motif domain containing 8 C Show summary »« Hide summary

Target Id

2525

Nomenclature

sterile alpha motif domain containing 8

Previous and unofficial names

Ceramide phosphoethanolamine synthase | CPE synthase | SAM domain-containing protein 8

Genes

SAMD8 (Hs), Samd8 (Mm), Samd8 (Rn)

Ensembl ID

ENSG00000156671 (Hs), ENSMUSG00000021770 (Mm), ENSRNOG00000013236 (Rn), ENSRNOG00000064565 (Rn)

UniProtKB AC

Q96LT4 (Hs), Q9DA37 (Mm), Q641X0 (Rn)

EC number

2.7.8.-

ceramide + phosphatidylethanolamine -> ceramide phosphoethanolamine

References

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1. Deng X, Lin F, Zhang Y, Li Y, Zhou L, Lou B, Li Y, Dong J, Ding T, Jiang X et al.. (2014) Identification of small molecule sphingomyelin synthase inhibitors. Eur J Med Chem, 73: 1-7. [PMID:24374347]

2. Li YL, Qi XY, Jiang H, Deng XD, Dong YP, Ding TB, Zhou L, Men P, Chu Y, Wang RX et al.. (2015) Discovery, synthesis and biological evaluation of 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamides (SAPAs) as novel sphingomyelin synthase 1 inhibitors. Bioorg Med Chem, 23 (18): 6173-84. [PMID:26314925]

3. Tani M, Kuge O. (2009) Sphingomyelin synthase 2 is palmitoylated at the COOH-terminal tail, which is involved in its localization in plasma membranes. Biochem Biophys Res Commun, 381 (3): 328-32. [PMID:19233134]

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.