UDP-glucose ceramide glucosyltransferase

Target id: 2528

Nomenclature: UDP-glucose ceramide glucosyltransferase

Family: Ceramide glucosyltransferase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for UDP-glucose ceramide glucosyltransferase in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 394 9q31 UGCG UDP-glucose ceramide glucosyltransferase
Mouse - 394 4 B3 Ugcg UDP-glucose ceramide glucosyltransferase
Rat - 394 5q24 Ugcg UDP-glucose ceramide glucosyltransferase
Previous and Unofficial Names
Epcs21 | GCS | GLCT-1 | Glucosylceramide synthase | Ugcgl
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.4.1.80 UDP-glucose + ceramide = uridine diphosphate + glucosylceramide

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
miglustat Hs Inhibition 5.1 pKi 1
pKi 5.1 (Ki 7.4x10-6 M) [1]

References

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1. Butters TD, van den Broek LAGM, Fleet GWJ, Krulle TM, Wormald MR, Dwek RA, Platt FM. (2000) Molecular requirements of imino sugars for the selective control of N-linked glycosylation and glycosphingolipid biosynthesis. Tetrahedron: Assymetry11 (1): 113-124.

How to cite this page

Ceramide glucosyltransferase: UDP-glucose ceramide glucosyltransferase. Last modified on 12/12/2013. Accessed on 19/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2528.