fatty acid binding protein 3

Target id: 2533

Nomenclature: fatty acid binding protein 3

Family: Fatty acid-binding proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for fatty acid binding protein 3 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 133 1p33-p32 FABP3 fatty acid binding protein 3
Mouse - 133 4 D2.2 Fabp3 fatty acid binding protein 3, muscle and heart
Rat - 133 5q36 Fabp3 fatty acid binding protein 3
Previous and Unofficial Names
FABP11 | Fabph1 | Fabph4 | fatty acid binding protein 11 | H-FABP | MDGI | mammary-derived growth inhibitor
Database Links
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Rank order of potency (Human)
stearic acid, oleic acid, palmitic acid > linoleic acid, α-linolenic acid, arachidonic acid  [1]

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 13 [PMID: 17502136] Hs Inhibition 8.4 pKi 2
pKi 8.4 (Ki 4x10-9 M) [2]

References

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1. Richieri GV, Ogata RT, Kleinfeld AM. (1994) Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart, and liver measured with the fluorescent probe ADIFAB. J. Biol. Chem., 269 (39): 23918-30. [PMID:7929039]

2. Sulsky R, Magnin DR, Huang Y, Simpkins L, Taunk P, Patel M, Zhu Y, Stouch TR, Bassolino-Klimas D, Parker R et al.. (2007) Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP). Bioorg. Med. Chem. Lett., 17 (12): 3511-5. [PMID:17502136]

How to cite this page

Fatty acid-binding proteins: fatty acid binding protein 3. Last modified on 29/01/2016. Accessed on 17/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2533.