retinol binding protein 4

Target id: 2549

Nomenclature: retinol binding protein 4

Family: Fatty acid-binding proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for retinol binding protein 4 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 201 10q23-q24 RBP4 retinol binding protein 4
Mouse - 201 19 D1 Rbp4 retinol binding protein 4, plasma
Rat - 201 1q53 Rbp4 retinol binding protein 4
Previous and Unofficial Names
PRBP | RBPA | retinol binding protein 4, plasma
Database Links
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of retinol-binding protein 4 (RBP4) in complex with non-retinoid ligand.
PDB Id:  3FMZ
Ligand:  A1120
Resolution:  2.9Å
Species:  Human
References:  1

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
A1120 Hs Inhibition 7.8 pIC50 2
pIC50 7.8 (IC50 1.4x10-8 M) [2]
Description: Measured using a FRET assay to monitor human RBP4–transthyretin interaction.

References

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1. Motani A, Wang Z, Conn M, Siegler K, Zhang Y, Liu Q, Johnstone S, Xu H, Thibault S, Wang Y et al.. (2009) Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivo. J. Biol. Chem.284 (12): 7673-80. [PMID:19147488]

2. Wang Y, Connors R, Fan P, Wang X, Wang Z, Liu J, Kayser F, Medina JC, Johnstone S, Xu H et al.. (2014) Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4. Bioorg. Med. Chem. Lett.24 (13): 2885-91. [PMID:24835984]

How to cite this page

Fatty acid-binding proteins: retinol binding protein 4. Last modified on 29/01/2016. Accessed on 20/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2549.