Vesicular polyamine transporter

Target id: 2556

Nomenclature: Vesicular polyamine transporter

Abbreviated Name: VPAT

Systematic Nomenclature: SLC18B1

Family: SLC18 family of vesicular amine transporters

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Vesicular polyamine transporter has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 456 6q22.3-q23.3 SLC18B1 solute carrier family 18 member B1
Mouse - 459 10 A3-A4 Slc18b1 solute carrier family 18
Rat - - 1p12 Slc18b1 solute carrier family 18 member B1
Previous and Unofficial Names
Solute carrier family 18 member B1 | solute carrier family 18, subfamily B, member 1
Database Links
Specialist databases
Bioparadigms SLC Tables SLC18B1 (Hs)
Other databases
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
spermine Hs - - 1
spermidine Hs - - 1
Immunopharmacology Comments
VPAT is expressed by mast cells and is responsible for vesicular storage of the polyamines, spermine and spermidine, in granules distinct from those containing histamine or serotonin [2]. VPAT is involved in vesicular release of these polyamines from mast cells.
Immuno Cell Type Associations
Immuno Cell Type:  Mast cells
Cell Ontology Term:   mast cell (CL:0000097)
Comment: 
References:  2

References

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1. Hiasa M, Miyaji T, Haruna Y, Takeuchi T, Harada Y, Moriyama S, Yamamoto A, Omote H, Moriyama Y. (2014) Identification of a mammalian vesicular polyamine transporter. Sci Rep4: 6836. [PMID:25355561]

2. Takeuchi T, Harada Y, Moriyama S, Furuta K, Tanaka S, Miyaji T, Omote H, Moriyama Y, Hiasa M. (2017) Vesicular Polyamine Transporter Mediates Vesicular Storage and Release of Polyamine from Mast Cells. J. Biol. Chem.292 (9): 3909-3918. [PMID:28082679]

How to cite this page

SLC18 family of vesicular amine transporters: Vesicular polyamine transporter. Last modified on 09/03/2017. Accessed on 17/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2556.