aldehyde dehydrogenase 2 family (mitochondrial)

Target id: 2595

Nomenclature: aldehyde dehydrogenase 2 family (mitochondrial)

Family: 1.-.-.- Oxidoreductases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for aldehyde dehydrogenase 2 family (mitochondrial) in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 261 12q24.12 ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
Mouse - 519 5 F-G1 Aldh2 aldehyde dehydrogenase 2, mitochondrial
Rat - 519 12q16 Aldh2 aldehyde dehydrogenase 2 family (mitochondrial)
Database Links
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CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
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RefSeq Nucleotide
RefSeq Protein
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Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Human Mitochondrial Aldehyde Dehydrogenase complexed with agonist Alda-1
PDB Id:  3INJ
Resolution:  1.69Å
Species:  Human
References:  3
Image of receptor 3D structure from RCSB PDB
Description:  Apo form of human mitochondrial aldehyde dehydrogenase
PDB Id:  1O05
Resolution:  2.25Å
Species:  Human
References:  1
Enzyme Reaction
EC Number: 1.2.1.3 an aldehyde + H2O + NAD = a carboxylate + 2H+ + NADH

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
prunetin Hs Inhibition 6.3 pKi 2
pKi 6.3 (Ki 4.5x10-7 M) In vitro inhibition of recombinant human mitochondrial alcohol dehydrogenase [2]
disulfiram Rn Inhibition 4.4 pIC50 4
pIC50 4.4 (IC50 3.64x10-5 M) [4]
View species-specific inhibitor tables
Clinically-Relevant Mutations and Pathophysiology
Disease:  Alcohol sensitivity
Synonyms: acetaldehyde dehydrogenase deficiency
alcohol flush reaction
OMIM: 610251
Role: 

References

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1. Hurley TD, Perez-Miller S, Breen H. (2001) Order and disorder in mitochondrial aldehyde dehydrogenase. Chem. Biol. Interact.130-132 (1-3): 3-14. [PMID:11306026]

2. Lowe ED, Gao GY, Johnson LN, Keung WM. (2008) Structure of daidzin, a naturally occurring anti-alcohol-addiction agent, in complex with human mitochondrial aldehyde dehydrogenase. J. Med. Chem.51 (15): 4482-7. [PMID:18613661]

3. Perez-Miller S, Younus H, Vanam R, Chen CH, Mochly-Rosen D, Hurley TD. (2010) Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant. Nat. Struct. Mol. Biol.17 (2): 159-64. [PMID:20062057]

4. Shen ML, Lipsky JJ, Naylor S. (2000) Role of disulfiram in the in vitro inhibition of rat liver mitochondrial aldehyde dehydrogenase. Biochem. Pharmacol.60 (7): 947-53. [PMID:10974203]

How to cite this page

1.-.-.- Oxidoreductases: aldehyde dehydrogenase 2 family (mitochondrial). Last modified on 13/08/2015. Accessed on 23/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2595.